In conclusion, we correlated expression and methylation changes in the <i>DLK1⁻DIO3</i> region, and we propose a complex model for regulation of this region in myelodysplasia.
A novel cell line derived from de novo acute myeloblastic leukaemia with trilineage myelodysplasia which proliferates in response to a Notch ligand, Delta-1 protein.
Examination of the Blast Bank samples from 22 patients with MDS, 31 with AML, and 8 with chronic myeloid leukemia confirmed the highly selective expression of the Dlk gene in the individuals with MDS.