Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE Also, autophagy-deficient ILC2s were adoptively transferred into Rag<sup>-/-</sup>GC<sup>-/-</sup> mice, which were then challenged with IL-33 and assessed for AHR and lung inflammation. 31738991 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 AlteredExpression disease BEFREE In vivo studies revealed that the indicators of pulmonary inflammation (pathology, inflammatory cell numbers) and related cytokines (IL-1β, IL-6, IL-33) mRNA expressions in CD11c-Map3k7<sup>-/-</sup> animals were significantly lower than wild-type animals after mice were instilled particles. 31330343 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE In this study, we investigated whether picroside II is effective in treating steroid refractory lung inflammation via the inhibition of the SAA-IL-33 axis. 31137813 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE Importantly, IL-33 (1 μg/kg) treatment significantly decreased mortality and pulmonary inflammation in A. baumannii-infected rats. 29508184 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE Airway epithelial injury, endothelial injury, and release of IL-33 are early events that subsequently promote eosinophil recruitment to the lung; eosinophilic infiltration and degranulation appear to mediate subsequent lung inflammation and associated clinical manifestations. 29206477 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE Accordingly, IL-6 and IL-33 neutralizing antibodies were used to explore which cytokine might play a key role in lung inflammation induced by BC and oBC. 29981970 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE We sought to examine the role of the IL-33/ST2 axis in lung inflammation on acute ozone exposure in mice. 29331644 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin. 29988569 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE Group 2 innate lymphoid cells (ILC2s) have recently been shown to play important roles in the initiation of allergic inflammation; however, it is unclear whether lipid mediators, such as cysteinyl leukotrienes (CysLTs), which are present in asthma, could further amplify the effects of IL-33 on ILC2 activation and lung inflammation. 28667163 2017
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 AlteredExpression disease BEFREE Finally, we show that hematopoietic AR expression limits IL-33-driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. 28484078 2017
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 AlteredExpression disease BEFREE Mice lacking mPGES-1 showed lower IL-33 levels and attenuated lung inflammation in response to repetitive <i>Alternaria</i> inhalation challenges. 28341741 2017
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE IL-33-mediated eosinophilic lung inflammation was not fully developed in T cell-deficient Foxn1 <sup>nu</sup> mice and NSG mice. 28754914 2017
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease CTD_human As a consequence house dust mite- and IL-33-driven lung inflammation, late phase cutaneous anaphylaxis, and collagen-induced arthritis were aggravated, in contrast to experimental autoimmune encephalomyelitis and immediate anaphylaxis. 24453940 2014
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE IL-33-mediated pulmonary inflammation may be glucocorticoid-resistant especially when other cytokines act synergistically. 25213717 2014
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE The unique capacity of Alternaria to drive this early IL-33 release resulted in a greater pulmonary inflammation by 24 hours after challenge relative to the common aeroallergen house dust mite. 24636086 2014
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE Moreover, the beneficial effect of sST2-Fc in allergic lung inflammation is related to blocking the IL-33/ST2L signalling. 22943195 2012
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE We biochemically determined the effect of IL-33 on mTOR activation in T(H)2 cells and ILCs and examined the effect of this signaling pathway in vivo using a murine model of IL-33-induced lung inflammation. 22738676 2012
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.400 Biomarker disease BEFREE In conclusion, IL-33 affects both the development of allergic sensitization and the development of lung inflammation in allergic asthma. 21618506 2011