Disease: Down Syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
A2M P01023 alpha-2-macroglobulin Enzyme modulator 4.5E-11 0.529 0.769
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923
ADAMTS1 Q9UHI8 ADAM metallopeptidase with thrombospondin type 1 motif 1 Enzyme 0.72 0.555 0.654
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
BACE1 P56817 beta-secretase 1 Enzyme 0.88 0.559 0.769
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923
CHRNA7 P36544 Q494W8 cholinergic receptor nicotinic alpha 7 subunit Ion channel 4.2E-04 0.532 0.654
CHRNB2 P17787 cholinergic receptor nicotinic beta 2 subunit Ion channel 7.3E-04 0.617 0.308
CLU P10909 clusterin 7.8E-05 0.426 0.885
CREB1 P16220 cAMP responsive element binding protein 1 1.00 0.463 0.885
CRMP1 Q14194 collapsin response mediator protein 1 Enzyme 0.99 0.525 0.808
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962
CST3 P01034 cystatin C 3.9E-03 0.436 0.808
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
DAPK2 Q9UIK4 death associated protein kinase 2 Kinase 5.0E-10 0.536 0.692
DENR O43583 density regulated re-initiation and release factor Enzyme 0.88 0.543 0.692