rs1801028
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We analyzed the DRD2 311Ser/Cys polymorphism in 312 German alcoholics and 131 ethnically matched controls to investigate the association of genetic DRD2 variants with alcoholism or clinical characteristics of homogeneous subgroups of alcoholics.
|
8727249 |
1996 |
rs1801028
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Therefore, we were able to provide a critical test of the D2 hypothesis of vulnerability to alcoholism by evaluating Ser311Cys and also the intron-2 STR and Taq1A markers at this locus in a total of 459 subjects, including 373 sib pairs, from large families.
|
9259374 |
1997 |
rs1801028
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genotyping of Ser311Cys, the DRD2 intron 2 STR, and the Taq1A marker in 459 subjects, including 373 sib-pairs and 15 Cys311/Cys311 homozygous individuals, revealed no association to alcoholism, substance use disorders, or schizophrenia.
|
9650635 |
1998 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In the Southwestern American Indian tribe, significant sib pair linkage of antisocial alcoholism</span> to HTR1B G861C (P=.01) was again observed, and there was also significant linkage to D6S284 (P=.01).
|
9819067 |
1998 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRM gene contributes a major effect to the pathogenesis of alcohol dependence.
|
9884158 |
1998 |
rs6318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This finding suggests that 5-HT2C receptors are involved in the regulation of norepinephrine turnover in humans; however, HTR2C Cys23Ser does not appear to contribute to the risk of alcoholism, or its contribution to this complex and heterogenous disorder is too small to be detected by a sample of this size and structure.
|
10494451 |
1999 |
rs6318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
5-HT2C Cys23Ser allele frequencies and genotypes did not differ among patients with alcohol dependence, panic disorder, generalized anxiety disorder, narcolepsy and normal healthy volunteers.
|
10994642 |
2000 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy.
|
11104852 |
2000 |
rs1805002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CCK(B) receptor polymorphism Val125Ile was also not associated with alcoholism and the Ile125 allele frequencies were 0.05 in controls vs. 0.06 in alcohol-dependent subjects.
|
11368834 |
2001 |
rs16139
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We have screened 200 Japanese workers and 105 Japanese patients with alcoholism for the mutation in the signal peptide of pre-pro-neuropeptide Y resulting in a substitution of proline for leucine at position 7.
|
11409703 |
2001 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present investigation we hypothesized the A118G (Asn40Asp) polymorphism of the mu-opioid receptor gene (OPRM1) as a particular vulnerability factor for heroin and alcohol dependence.
|
11424981 |
2001 |
rs6313
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There was no association between the 5-HT2A receptor polymorphism (T102C</span>), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients.
|
11444684 |
2001 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Consequently, genes encoding serotonin (5-HT) receptors are candidates for genetic studies of both disorders. found evidence for linkage of antisocial alcoholism to HTR1B (the locus encoding the 5-HT1B receptor) in both Finns and Southwestern American Indians, and of allelic association of a G861C polymorphism at that locus with antisocial alcoholism in Finns.
|
11751038 |
2002 |
rs16139
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States.
|
12215082 |
2002 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
There exists preliminary evidence for association of G861C with i) antisocial alcoholism in the Finnish; ii) alcoholism in the presence of inactive aldehyde dehydrogenase 2 in the Japanese; iii) a history of suicide attempts in European-American personality disorder patients; and iv) minimum lifetime body mass index in Canadian bulimia nervosa patients.
|
12437478 |
2002 |
rs6296
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No significant association of the genotype or allele frequencies of the h5-HTR(1B) G861C locus was observed with diagnoses of alcoholism, bipolar disorder, schizophrenia or a history of a suicide attempt.
|
12496953 |
2003 |
rs16139
|
|
|
0.040 |
GeneticVariation |
BEFREE |
NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations.
|
12544000 |
2003 |
rs780312650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of this functional variant in 463 Southwestern Native Americans revealed no significant association between the DUSP8 C712T (Ala193Val) polymorphism and alcohol dependence (odds ratio = 1.48 95% CI 0.6-3.92).
|
13129832 |
2003 |
rs6318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In our sample, the functional relevant 5-HTT promoter and the 5-HT2c receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
|
14574222 |
2003 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His.
|
15048643 |
2004 |
rs324650
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome.
|
15229186 |
2004 |
rs2061174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome.
|
15229186 |
2004 |
rs2239670
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we report for the first time that the AvaII polymorphism (rs2239670) in intron 1 of the CART gene is associated with alcoholism in the Korean male population.
|
15234472 |
2004 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that having one or two copies of the A118G allele is common among Koreans and may be an important genetic factor in the etiology of alcohol dependence and the frequency of alcohol consumption.
|
15252283 |
2004 |
rs34315573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PCR-based assays showed that alcoholism was associated with polymorphisms of the dopamine D2 receptor (DRD2) TaqI B (P = .029) and the GABAA-beta2 subunit C1412T (P = .012) genes, but not with the glutamate receptor subunit gene NMDAR2B (366C/G), the serotonin transporter gene (5HTTL-PR), the dopamine transporter gene DAT1(SLC6A3), the dopamine D2 receptor gene DRD2 TaqI A, or the GABAA alpha1(A15G), alpha6(T1519C), and gamma2(G3145A) subunit genes.
|
15542698 |
2004 |