|
rs1034936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder.
|
31634677 |
2020 |
|
rs2066713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs4251417
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs1799913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When patients with comorbid alcohol use disorder (AUD) were removed, given that TPH1 has been associated with alcoholism, the associations of those recovered from SI with TPH1 rs1799913 remained significant for the additive (increased recovery with AC, P = 0.045) and recessive (increased recovery with C-carriers, P = 0.008) models, and with 5-HTTLPR using the dominant model (increased recovery with S'S', P = 0.016).
|
30923939 |
2019 |
|
rs188227250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the EA GWAS, three loci were genome-wide significant: rs1229984 in ADH1B for AD criterion count (P = 4.16E-11) and Desire to cut drinking (P = 1.21E-11); rs188227250 (chromosome 8, Drinking more than intended, P = 6.72E-09); rs1912461 (chromosome 15, Time spent drinking, P = 1.77E-08).
|
31090166 |
2019 |
|
rs1890881
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One GWS region (chromosome 1: rs1890881) emerged from a trans-ancestral meta-analysis (EA + AA) of ANYDEP, and was attributable to alcohol dependence in both samples.
|
31099175 |
2019 |
|
rs1912461
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the EA GWAS, three loci were genome-wide significant: rs1229984 in ADH1B for AD criterion count (P = 4.16E-11) and Desire to cut drinking (P = 1.21E-11); rs188227250 (chromosome 8, Drinking more than intended, P = 6.72E-09); rs1912461 (chromosome 15, Time spent drinking, P = 1.77E-08).
|
31090166 |
2019 |
|
rs2290045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors.
|
30805764 |
2019 |
|
rs3219151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
High frequency of GABRA6 rs3219151 TT genotype in AD and its association with lower age at first use, higher intake/day, and higher duration of dependence appears to confer risk.
|
29673739 |
2019 |
|
rs61826952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the trans-ancestral meta-analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome-wide significant: rs61826952 (chromosome 1, DSM-IV AD, P = 8.42E-11); rs7597960 (chromosome 2, Time spent drinking, P = 1.22E-08).
|
31090166 |
2019 |
|
rs7597960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the trans-ancestral meta-analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome-wide significant: rs61826952 (chromosome 1, DSM-IV AD, P = 8.42E-11); rs7597960 (chromosome 2, Time spent drinking, P = 1.22E-08).
|
31090166 |
2019 |
|
rs10514299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analyses in the NIAAA sample showed a trend-level relationship between rs10514299 and a lifetime AD diagnosis in the European American subgroup (odds ratio = 0.82, p = 0.09).
|
30006604 |
2018 |
|
rs1131445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms.
|
29566963 |
2018 |
|
rs1368439
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms.
|
29566963 |
2018 |
|
rs143894582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All 3 traits showed genomewide significant association with variants near ALDH2, with significance ranging from 2.01 × 10<sup>-14</sup> (for flushing; lead single nucleotide polymorphism (SNP) PTPN11* rs143894582) to p<sub>meta</sub> = 5.80 × 10<sup>-10</sup> (for alcohol dependence criterion count; lead SNP rs149212747).
|
29460428 |
2018 |
|
rs149212747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All 3 traits showed genomewide significant association with variants near ALDH2, with significance ranging from 2.01 × 10<sup>-14</sup> (for flushing; lead single nucleotide polymorphism (SNP) PTPN11* rs143894582) to p<sub>meta</sub> = 5.80 × 10<sup>-10</sup> (for alcohol dependence criterion count; lead SNP rs149212747).
|
29460428 |
2018 |
|
rs2952621
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We then performed a meta-analysis of the two samples used in the original study that reported the association of rs2952621 with substance dependence (Collaborative Studies on Genetics of Alcoholism (COGA) and Study of Addiction: Genetics and Environment (SAGE)) together with our Spanish sample.
|
29715653 |
2018 |
|
rs324420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings provide evidence that the Pro129Thr missense variant is associated with AD severity in European Americans.
|
28150397 |
2018 |
|
rs3917328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms.
|
29566963 |
2018 |
|
rs4648143
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms.
|
29566963 |
2018 |
|
rs774062108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms.
|
29566963 |
2018 |
|
rs778338788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms.
|
29566963 |
2018 |
|
rs878081
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased RA risk among non-smokers.
|
30403260 |
2018 |
|
rs940553638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs1137070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1137070 polymorphism of monoamine oxidase A (MAOA) is associated with alcoholism and smoking behavior.
|
28345608 |
2017 |