rs1000579
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
rs1000579
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
rs1000579
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
rs10009145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype ATAAAT, which contained the minor allele of rs10009145 and the major allele of rs7689753, increased the risk of alcohol dependence, whereas haplotype GGGGAT, bearing the major allele of rs10009145 and the minor allele of rs7689753, protected against it.
|
22044940 |
2012 |
rs10051667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two additional SNPs, rs10051667 (S31) and rs967771 (S32), previously associated with alcohol dependence and bipolar disorder respectively, were also analyzed.
|
26561861 |
2015 |
rs10160548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B).
|
23757001 |
2013 |
rs1017418
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Applying this method to the Genetic Analysis Workshop 14 alcoholism data, we find that markers rs716581, rs1017418, rs1332184 and rs1943418 on chromosomes 1, 2, 9 and 18 yield strong signal (with P value 0.001 or lower) for association with alcoholism.
|
17530290 |
2007 |
rs10196867
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>).
|
31462767 |
2019 |
rs10196867
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>).
|
31462767 |
2019 |
rs10198241
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.
|
29071344 |
2017 |
rs10211296
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.
|
28990359 |
2017 |
rs1034866440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
rs1034936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder.
|
31634677 |
2020 |
rs1039002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸).
|
22205951 |
2011 |
rs10392
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
rs1042114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (chi(2)=14.82, degrees of freedom (d.f.)=1, P<0.001), CD (chi(2)=9.19, d.f.=1, P=0.002) and OD (chi(2)=20.68, d.f.=1, P<0.001).
|
17622222 |
2008 |
rs1042173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B).
|
23757001 |
2013 |
rs1042363
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed that: (i) the genotypes of SNP2 (rs1042363) were significantly associated with alcohol dependence and drug dependence (mainly cocaine dependence), and the genotypes of SNP3 (rs1126671) were also significantly associated with alcohol dependence and (ii) one seven-variant haplotype and one diplotype were significantly associated with alcohol dependence and other seven-variant diplotypes were significantly associated with drug dependence (including cocaine and opioid dependence).
|
16220108 |
2005 |
rs1042363
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among all markers, SNP2 (rs1042363) at exon 9 or SNP6 (rs1800759) at the promoter showed the greatest degree of HWD, among patients with either alcohol dependence or drug dependence.
|
16237392 |
2006 |
rs1042364
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms.
|
27172571 |
2016 |
rs1042364
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both variants--rs1800759 and rs10</span>42364--and the A-A and C-G haplotypes were significantly related to AD across samples.
|
20626721 |
2011 |
rs10483038
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
|
22554406 |
2012 |
rs10496768
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
rs10514299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analyses in the NIAAA sample showed a trend-level relationship between rs10514299 and a lifetime AD diagnosis in the European American subgroup (odds ratio = 0.82, p = 0.09).
|
30006604 |
2018 |
rs1051740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found significant association between EPHX1 gene Tyr113His polymorphism and alcoholism in the Kota population (T vs. C: OR = .615, 95% CI = .399-.949, p = .027; TT vs. CC + CT: OR = .536, 95% CI = .297-.969, p = .038).
|
22257321 |
2013 |