Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1000579
rs1000579
0.800 GeneticVariation GWASCAT Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012

dbSNP: rs1000579
rs1000579
0.800 GeneticVariation GWASDB Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012

dbSNP: rs1000579
rs1000579
G 0.800 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907

2017

dbSNP: rs10009145
rs10009145
0.010 GeneticVariation BEFREE Haplotype ATAAAT, which contained the minor allele of rs10009145 and the major allele of rs7689753, increased the risk of alcohol dependence, whereas haplotype GGGGAT, bearing the major allele of rs10009145 and the minor allele of rs7689753, protected against it. 22044940

2012

dbSNP: rs10051667
rs10051667
0.010 GeneticVariation BEFREE Two additional SNPs, rs10051667 (S31) and rs967771 (S32), previously associated with alcohol dependence and bipolar disorder respectively, were also analyzed. 26561861

2015

dbSNP: rs10160548
rs10160548
0.010 GeneticVariation BEFREE Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B). 23757001

2013

dbSNP: rs1017418
rs1017418
0.010 GeneticVariation BEFREE Applying this method to the Genetic Analysis Workshop 14 alcoholism data, we find that markers rs716581, rs1017418, rs1332184 and rs1943418 on chromosomes 1, 2, 9 and 18 yield strong signal (with P value 0.001 or lower) for association with alcoholism. 17530290

2007

dbSNP: rs10196867
rs10196867
0.710 GeneticVariation BEFREE We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>). 31462767

2019

dbSNP: rs10196867
rs10196867
C 0.710 GeneticVariation GWASCAT We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>). 31462767

2019

dbSNP: rs10198241
rs10198241
C 0.700 GeneticVariation GWASCAT Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. 29071344

2017

dbSNP: rs10211296
rs10211296
0.700 GeneticVariation GWASCAT Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. 28990359

2017

dbSNP: rs1034866440
rs1034866440
AR
0.010 GeneticVariation BEFREE In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving. 22707254

2012

dbSNP: rs1034936
rs1034936
0.010 GeneticVariation BEFREE Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder. 31634677

2020

dbSNP: rs1039002
rs1039002
0.010 GeneticVariation BEFREE Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸). 22205951

2011

dbSNP: rs10392
rs10392
A 0.700 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907

2017

dbSNP: rs1042114
rs1042114
0.010 GeneticVariation BEFREE Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (chi(2)=14.82, degrees of freedom (d.f.)=1, P<0.001), CD (chi(2)=9.19, d.f.=1, P=0.002) and OD (chi(2)=20.68, d.f.=1, P<0.001). 17622222

2008

dbSNP: rs1042173
rs1042173
0.010 GeneticVariation BEFREE Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B). 23757001

2013

dbSNP: rs1042363
rs1042363
0.020 GeneticVariation BEFREE Logistic regression analysis showed that: (i) the genotypes of SNP2 (rs1042363) were significantly associated with alcohol dependence and drug dependence (mainly cocaine dependence), and the genotypes of SNP3 (rs1126671) were also significantly associated with alcohol dependence and (ii) one seven-variant haplotype and one diplotype were significantly associated with alcohol dependence and other seven-variant diplotypes were significantly associated with drug dependence (including cocaine and opioid dependence). 16220108

2005

dbSNP: rs1042363
rs1042363
0.020 GeneticVariation BEFREE Among all markers, SNP2 (rs1042363) at exon 9 or SNP6 (rs1800759) at the promoter showed the greatest degree of HWD, among patients with either alcohol dependence or drug dependence. 16237392

2006

dbSNP: rs1042364
rs1042364
0.020 GeneticVariation BEFREE The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. 27172571

2016

dbSNP: rs1042364
rs1042364
0.020 GeneticVariation BEFREE Both variants--rs1800759 and rs10</span>42364--and the A-A and C-G haplotypes were significantly related to AD across samples. 20626721

2011

dbSNP: rs10483038
rs10483038
0.700 GeneticVariation GWASDB Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6. 22554406

2012

dbSNP: rs10496768
rs10496768
0.010 GeneticVariation BEFREE The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively). 21703634

2011

dbSNP: rs10514299
rs10514299
0.010 GeneticVariation BEFREE Association analyses in the NIAAA sample showed a trend-level relationship between rs10514299 and a lifetime AD diagnosis in the European American subgroup (odds ratio = 0.82, p = 0.09). 30006604

2018

dbSNP: rs1051740
rs1051740
0.010 GeneticVariation BEFREE We found significant association between EPHX1 gene Tyr113His polymorphism and alcoholism in the Kota population (T vs. C: OR = .615, 95% CI = .399-.949, p = .027; TT vs. CC + CT: OR = .536, 95% CI = .297-.969, p = .038). 22257321

2013