rs1229984
|
|
|
0.900 |
GeneticVariation |
GWASDB |
In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
|
23456092 |
2013 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect.
|
21968928 |
2012 |
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Individuals heterozygous or homozygous for the lys (A or *2) allele at the single nucleotide polymorphism (SNP) glu504lys (rs671) of ALDH2 have greatly reduced ability to metabolize acetaldehyde, which greatly decreases their risk for alcohol dependence (AD).
|
22102315 |
2012 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism.
|
19710201 |
2010 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population.
|
20180859 |
2010 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Carrying the alcohol dehydrogenase 1B 48His allele (rs1229984 or ADH1B*2) could decrease the risk of alcoholism, but with persistent drinking may confer a greater risk of CLDs.
|
20219057 |
2010 |
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population.
|
20180859 |
2010 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism.
|
16086315 |
2005 |
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Data presented show that antialcohol drugs that inhibit Aldh2 gene expression can be generated endogenously in liver cells infected by an adenoviral vector carrying an antisense-coding gene, thus mimicking the high-acetaldehyde phenotype that exists in humans carrying the Glu487Lys mutation who are protected against alcoholism.
|
16131845 |
2005 |
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His.
|
15048643 |
2004 |
rs1789891
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Recent genome-wide systematic searches found associations between a single nucleotide polymorphism (rs1789891, risk allele: A, protective allele: C) in the alcohol dehydrogenase gene cluster and the risk of alcohol dependence.
|
29058369 |
2019 |
rs1789891
|
|
A |
0.820 |
GeneticVariation |
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
rs1789891
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders.
|
26013422 |
2015 |
rs1789891
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
rs1789891
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
rs750338
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
rs750338
|
|
C |
0.810 |
GeneticVariation |
GWASDB |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
rs750338
|
|
C |
0.810 |
GeneticVariation |
GWASCAT |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
rs1000579
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
rs896543
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
24962325 |
2014 |
rs4478858
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
|
23455491 |
2013 |
rs4478858
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
|
23455491 |
2013 |
rs896543
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
|
23089632 |
2013 |
rs1000579
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
rs1000579
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |