|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings demonstrate that these variants, which were highly linked with ALDH2 rs671 and ADH1B rs1229984, were significant modulators for AD in our Han Chinese cohort.
|
31591379 |
2019 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the EA GWAS, three loci were genome-wide significant: rs1229984 in ADH1B for AD criterion count (P = 4.16E-11) and Desire to cut drinking (P = 1.21E-11); rs188227250 (chromosome 8, Drinking more than intended, P = 6.72E-09); rs1912461 (chromosome 15, Time spent drinking, P = 1.77E-08).
|
31090166 |
2019 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
In the trans-ancestral meta-analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome-wide significant: rs61826952 (chromosome 1, DSM-IV AD, P = 8.42E-11); rs7597960 (chromosome 2, Time spent drinking, P = 1.22E-08).
|
31090166 |
2019 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The inclusion of rs1229984 attenuated the effects of the alcohol consumption PRS, particularly for DSM4AD and DSM5AUDSX, but the PRS continued to exert an independent effect for all 5 alcohol measures (Δmarginal R<sup>2</sup> after controlling for ADH1B = 0.14 to 1.22%).
|
30994927 |
2019 |
|
rs1229984
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a genome-wide association study (GWAS), we identified highly significant associations between two population-specific functional variants in the alcohol dehydrogenase 1B gene (ADH1B) and AD in African-Americans (AAs; rs2066702) and European-Americans (EAs; rs1229984).
|
25828809 |
2016 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed.
|
27172571 |
2016 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, the rare ADH1B rs1229984 mutation provides significant protection against ADS in this British and Irish population; other variants in the ADH gene cluster also alter ADS risk, although the strong linkage disequilibrium between SNPs at this location precluded clear identification of the variant(s) driving the associations.
|
24735490 |
2015 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
rs1229984
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism.
|
23969552 |
2014 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
|
23456092 |
2013 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
|
23456092 |
2013 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
GWASDB |
In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35).
|
23456092 |
2013 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect.
|
21968928 |
2012 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism.
|
19710201 |
2010 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population.
|
20180859 |
2010 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Carrying the alcohol dehydrogenase 1B 48His allele (rs1229984 or ADH1B*2) could decrease the risk of alcoholism, but with persistent drinking may confer a greater risk of CLDs.
|
20219057 |
2010 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism.
|
16086315 |
2005 |
|
rs1229984
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His.
|
15048643 |
2004 |