DisGeNET - a database of gene-disease associations

Alcoholic Intoxication, Chronic, C0001973

Variant: rs2066702 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2066702

ADH1B

0.720

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs2066702

ADH1B

0.720

GeneticVariation

BEFREE

In a genome-wide association study (GWAS), we identified highly significant associations between two population-specific functional variants in the alcohol dehydrogenase 1B gene (ADH1B) and AD in African-Americans (AAs; rs2066702) and European-Americans (EAs; rs1229984).

25828809

2016

dbSNP:

rs2066702

ADH1B

0.720

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs2066702

ADH1B

0.720

GeneticVariation

BEFREE

We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.

25410943

2014