Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454

2018

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In conclusion, the rare ADH1B rs1229984 mutation provides significant protection against ADS in this British and Irish population; other variants in the ADH gene cluster also alter ADS risk, although the strong linkage disequilibrium between SNPs at this location precluded clear identification of the variant(s) driving the associations. 24735490

2016

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively. 25410943

2015

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism. 23969552

2014

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASCAT Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. 24166409

2014

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASCAT Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. 23456092

2013

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35). 23456092

2013

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation GWASDB Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. 23456092

2013

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. 21968928

2012

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. 19710201

2010

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Carrying the alcohol dehydrogenase 1B 48His allele (rs1229984 or ADH1B*2) could decrease the risk of alcoholism, but with persistent drinking may confer a greater risk of CLDs. 20219057

2010

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population. 20180859

2010

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism. 16086315

2006

dbSNP: rs1229984
rs1229984
0.900 GeneticVariation BEFREE In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. 15048643

2004

dbSNP: rs671
rs671
0.860 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454

2018

dbSNP: rs671
rs671
0.860 GeneticVariation BEFREE Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. 28728635

2018

dbSNP: rs671
rs671
0.860 GeneticVariation BEFREE To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample. 25372623

2015

dbSNP: rs671
rs671
0.860 GeneticVariation GWASCAT ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. 24277619

2014

dbSNP: rs671
rs671
0.860 GeneticVariation BEFREE When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks. 24277619

2014

dbSNP: rs671
rs671
0.860 GeneticVariation GWASDB ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. 24277619

2014

dbSNP: rs671
rs671
0.860 GeneticVariation BEFREE Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism. 23969552

2014

dbSNP: rs671
rs671
0.860 GeneticVariation BEFREE Individuals heterozygous or homozygous for the lys (A or *2) allele at the single nucleotide polymorphism (SNP) glu504lys (rs671) of ALDH2 have greatly reduced ability to metabolize acetaldehyde, which greatly decreases their risk for alcohol dependence (AD). 22102315

2012

dbSNP: rs1789891
rs1789891
0.810 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907

2017

dbSNP: rs1789891
rs1789891
0.810 GeneticVariation BEFREE The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders. 26013422

2016

dbSNP: rs1789891
rs1789891
0.810 GeneticVariation GWASDB Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. 22004471

2012