Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs116855232
rs116855232
0.750 GeneticVariation GWASCAT We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89). 29923122

2018

dbSNP: rs116855232
rs116855232
0.750 GeneticVariation BEFREE We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89). 29923122

2018

dbSNP: rs116855232
rs116855232
0.750 GeneticVariation BEFREE Therefore, the NUDT15 p.R139C variant is common and strongly associated with AZA-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases. 28566182

2017

dbSNP: rs116855232
rs116855232
0.750 GeneticVariation BEFREE NUDT15 R139C (rs116855232) is a recently identified genetic factor responsible for thiopurine-induced leukocytopenia and hair loss. 26590936

2016

dbSNP: rs116855232
rs116855232
0.750 GeneticVariation BEFREE Extensive hair loss was a recognizable early symptom in patients with the homozygous NUDT15 c.415C>T variant. 26735160

2016

dbSNP: rs116855232
rs116855232
0.750 GeneticVariation BEFREE NUDT R139C was significantly associated with early severe hair loss in Japanese patients with IBD. 26076924

2016