Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE The present meta-analysis suggests that rs12608932(C) is associated with increased ALS susceptibility, especially in Caucasian and European subjects, and that the CC genotype of rs12608932 is associated with reduced ALS patient survival. 31201598

2019
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE Our findings demonstrate converging evidence that rs12608932 may modify frontotemporal disease in sporadic ALS and suggest that rs12608932 may function as a prognostic indicator and could be used to define patient endophenotypes in clinical trials. 30368160

2019
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation GWASCAT Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348

2016
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE 136 sporadic ALS (sALS) patients and 487 healthy controls were genotyped for the UNC13A rs12608932 variant. 26162714

2015
dbSNP: rs12608932
rs12608932
UNC13A
C 0.880 GeneticVariation GWASDB No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. 24234648

2014
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE Recently, four single nucleotide polymorphisms (SNPs), including rs2814707 in the 9p21, rs12608932 in the UNC13A gene, rs13048019 in the TIMA1 gene, and rs2228576 in the SCNN1A gene have been reported to be associated with the risk for developing amyotrophic lateral sclerosis (ALS) in Caucasian population. 24493373

2014
dbSNP: rs12608932
rs12608932
UNC13A
C 0.880 GeneticVariation GWASCAT C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis. 24931836

2014
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE Overall, minor allele carrier status of rs12608932 was strongly associated with an approximate 1-year reduction of survival in ALS patients, making it a significant determinant of phenotype variation. 22921269

2013
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)). 22959728

2013
dbSNP: rs12608932
rs12608932
UNC13A
C 0.880 GeneticVariation GWASCAT Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)). 22959728

2013
dbSNP: rs12608932
rs12608932
UNC13A
C 0.880 GeneticVariation GWASDB Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)). 22959728

2013
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE In both cohorts, the minor allele of rs12608932 in UNC13A was not only associated with susceptibility but also with shorter survival of ALS patients. 22118904

2012
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation BEFREE We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. 21295378

2011
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation GWASDB Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. 20801717

2010
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation GWASCAT Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. 19734901

2009
dbSNP: rs12608932
rs12608932
UNC13A
0.880 GeneticVariation GWASDB Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. 19734901

2009