rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The baseline haemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anaemia at 4, 8 and 12 weeks of RBV therapy.
|
28543275 |
2017 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In 106 patients treated with SOF/RBV therapy, this study assessed the effects of the ITPA polymorphism (rs1127354) on anemia, RBV dose reduction, and sustained virological response.
|
28109022 |
2017 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.
|
28480960 |
2017 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The ITPA rs1127354 CC and rs6051702 AA genotypes may predict ribavirin-induced anemia during treatment with interferon-free, ribavirin-containing regimens.
|
26650626 |
2015 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Anaemia was observed in 87.5% and 86.2% of treated patients with AA (rs7270101) and CC genotypes (rs1127354), respectively.
|
26154744 |
2015 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The ITPA SNP rs1127354 is a useful predictor of ribavirin-induced anemia in Taiwanese patients and may be related to more severe decreases in platelet counts during the early stage of HCV combination therapy.(Gut Liver, 2015;9214-223).
|
25287171 |
2015 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The incidence of severe anaemia, ≥ 3 g/dL reduction or <10 g/dL of haemoglobin (Hb) up to week 12, was more frequent in patients with CC at rs1127354 [65% (145/224), 33% (73/224)] than in those with CA/AA [25% (21/85), 6% (8/85)] (P < 0.0001).
|
24750345 |
2014 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The inosine triphosphatase CC allele (rs1127354) was independently associated with the development of severe anaemia, and lower serum albumin level (<35 g/L) was associated with the occurrence of infection.
|
24099469 |
2013 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ITPA rs1127354 CA genotype, when compared to CC genotype, was associated with lesser degree of anaemia throughout therapy (P < 0.05 for all time points).
|
23730840 |
2013 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR.
|
23960450 |
2013 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In multivariate logistic regression analyses the carrier of a variant allele in the rs6051702/rs1127354 association (OR=0.11, p=1.75×10(-5)) and Hb at baseline (OR=1.51, p=1.21×10(-4)) were independently associated with protection against clinically significant anemia at week 4.
|
23933495 |
2013 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of our study was to genotype patients for inosine triphosphatase gene polymorphism rs1127354 SNP (CC or CA) and associate treatment-induced anaemia with gene expression profile and genotypes.
|
22571903 |
2012 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ITPA rs1127354 is useful for the prediction of ribavirin-induced anemia in the early phase after the commencement of peginterferon plus ribavirin treatment and IL28B rs8099917 is useful for the prediction of sustained virological response.
|
23012624 |
2012 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the model could not be constructed, because no patients with rs1127354 minor genotype CA/AA had significant anemia.
|
23139603 |
2012 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The ITPA variants were strongly and independently associated with protection from week 4 anemia (P = 10(-6) for rs1127354 and P = 10(-7) for rs7270101).
|
21274861 |
2011 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data suggests that measures to prevent anemia should be considered for patients who have pretreatment hemoglobin levels less than 13.5 g/dl or who have rs1127354 genotype CC and pretreatment hemoglobin levels between 13.5 and 15 g/dl.
|
21503919 |
2011 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genotype 1b chronic hepatitis C patients (n=132) treated with pegylated interferon (PEG-IFN)-α and RBV for 48 weeks were genotyped for ITPA rs1127354 and examined for anaemia and treatment outcome.
|
21817190 |
2011 |
rs1127354
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection.
|
22028438 |
2011 |
rs1127354
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Multivariate analysis demonstrated that age, baseline Hb, baseline platelet count, and rs1127354 were independently associated with severe anemia (Hb <10 g/dL).
|
20637204 |
2010 |
rs1127354
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Multivariate analysis demonstrated that age, baseline Hb, baseline platelet count, and rs1127354 were independently associated with severe anemia (Hb <10 g/dL).
|
20637204 |
2010 |
rs1559810905
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
An extremely severe case of Aicardi-Goutières syndrome 7 with a novel variant in IFIH1.
|
30965144 |
2020 |
rs776035233
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.
|
31164121 |
2019 |
rs779114194
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.
|
31164121 |
2019 |
rs987710
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies genetic loci associated with iron deficiency.
|
21483845 |
2011 |