|
rs111854391
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs112550005
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs665268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that rs665268 significantly correlated with the severity of TAK, including the number of arterial lesions and morbidity of aortic regurgitation; the latter may be attributed to the fact that MLX mRNA expression was mostly detected in the aortic valve.
|
30354298 |
2018 |
|
rs77041280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AR patients with mutant genotype (TA + AA) of rs77485247 and AR patients with mutant genotype (AT + TT) of rs77041280 had higher specific IgE, ECP levels, and VAS scores after treatment and lower incidence of adverse reactions and total effective rate than those with TT genotype and those with AA genotype, respectively.
|
27888642 |
2017 |
|
rs77485247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AR patients with mutant genotype (TA + AA) of rs77485247 and AR patients with mutant genotype (AT + TT) of rs77041280 had higher specific IgE, ECP levels, and VAS scores after treatment and lower incidence of adverse reactions and total effective rate than those with TT genotype and those with AA genotype, respectively.
|
27888642 |
2017 |
|
rs772341885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we demonstrate that an expanded p63<sup>+</sup> and CK5<sup>+</sup> basal/progenitor cell population, induced by the concomitant activation of oncogenic Kras(G12D) and androgen receptor (AR) signaling, underwent cell differentiation in vivo The differentiation process led to suppression of p63-expressing cells with a decreased number of CK5<sup>+</sup> basal cells but an increase of CK8<sup>+</sup> luminal tumorigenic cells and revealed a hierarchal lineage pattern consisting of p63<sup>+</sup>/CK5<sup>+</sup> progenitor, CK5<sup>+</sup>/CK8<sup>+</sup> transitional progenitor, and CK8<sup>+</sup> differentiated luminal cells.
|
27760825 |
2016 |
|
rs2515641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2515641 of CYP2E1 showed significant differences between the AR patient group and non-AR group (p = 0.003, OR = 2.55, 95% CI = 1.37-4.75 in the codominant 1 model; p = 0.002, OR = 2.61, 95% CI = 1.43-4.77 in the dominant model; p = 0.0035, OR = 2.13, 95% CI = 1.29-3.50 in the log-additive model).
|
24654912 |
2014 |
|
rs6871626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that rs6871626 showed a significant association with clinical manifestations of TAK, including increased risk and severity of aortic regurgitation, a representative severe complication of TAK.
|
23830516 |
2013 |