rs1063539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
rs11545078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to look for the association of FPGS 2752 G > A (rs1544105), FPGS 1994 A > G (rs10106), and GGH 452 C > T (rs 11545078), GGH -401C > T (rs 3758149) gene polymorphisms with methotrexate (MTX) treatment response and MTX-induced adverse events in South Indian Tamil patients with rheumatoid arthritis (RA).
|
31611592 |
2020 |
rs12342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
rs1348254052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to look for the association of FPGS 2752 G > A (rs1544105), FPGS 1994 A > G (rs10106), and GGH 452 C > T (rs 11545078), GGH -401C > T (rs 3758149) gene polymorphisms with methotrexate (MTX) treatment response and MTX-induced adverse events in South Indian Tamil patients with rheumatoid arthritis (RA).
|
31611592 |
2020 |
rs1544105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to look for the association of FPGS 2752 G > A (rs1544105), FPGS 1994 A > G (rs10106), and GGH 452 C > T (rs 11545078), GGH -401C > T (rs 3758149) gene polymorphisms with methotrexate (MTX) treatment response and MTX-induced adverse events in South Indian Tamil patients with rheumatoid arthritis (RA).
|
31611592 |
2020 |
rs1800796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relationship between polymorphisms in -572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta-analysis.
|
31782615 |
2020 |
rs2069705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we verified higher IL-6 value in the RA patients than healthy control group (p = 0.007) and an association between high IL-6 levels and increased CDAI (r = 0.4648, p = 0.0015); DAS 28 (r = 0.3933, p= 0.0091), presence of bone erosions (r = 0.3170, p = 0.0361), ESR levels(r = 0.3041, p = 0.0448) and IFN-γ levels (r = 0.3049, p = 0.0468).Altogether, we suggest that IL10 -1082 (T>C, rs1800896) and INFG -1616(A>G, rs2069705) polymorphisms as well as IL-6 levels alterations may play a role for prognostic and disease follow-up.
|
31494241 |
2020 |
rs2082940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
rs5844572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the association of MIF promoter polymorphisms (-794CATT<sub>5-8</sub> rs5844572 and -173G > C, rs755622), circulating MIF levels, and mRNA expression with RA susceptibility and disease activity.
|
31701681 |
2020 |
rs7539542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
rs11137037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The subjects with A/C and C/C genotype of SNP rs11137037 were 1.65 and 2.04 times likely to develop RA than the subjects with A/A genotype.
|
30745815 |
2019 |
rs11203203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we did not detect any significant associations between rs11203203 and RA susceptibility and autoantibody profiles (all p>.05).
|
30822156 |
2019 |
rs117026326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variant rs117026326 upstream of the general transcription factor II-I (GTF2I) has been associated with primary Sjögren's syndrome, SLE and RA in East Asian populations.
|
31520790 |
2019 |
rs1234315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant associations with SLE and RA were detected at rs1234315, both by allele analysis (odds ratio 1.47, 95% confidence interval 1.17-1.86, p = 0.001; odds ratio 1.49, 95% confidence interval 1.15-1.92, p = 0.002; respectively), and genotype analysis (p = 0.003 and p = 7.000 × 10<sup>-5</sup>, respectively).
|
30468820 |
2019 |
rs12537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results identify a novel role of rs12537 in the susceptibility and progression of RA and SLE, possibly through impacting the interaction between miR-181a and MTMR3 leading to increased autophagy.
|
31444373 |
2019 |
rs12674822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The subjects with G/T and T/T genotype of SNP rs12674822 were 2.42 and 2.25 times likely to develop RA than the subjects with G/G genotype.
|
30745815 |
2019 |
rs1689334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study genotyped blood samples from 214 patients with rheumatoid arthritis (RA) and 293 healthy controls for single nucleotide polymorphisms (SNPs) rs2977537, rs2929970, rs2929973, rs2977530, rs1689334 and rs62514004.
|
31689765 |
2019 |
rs17221959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS This study suggested that the TT genotype and T allele in rs17221959 decreased RA risk.
|
31316048 |
2019 |
rs1805034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis found that the rs2277438 polymorphism in <i>RANKL</i> gene inc</span>reased the risk of RA, whereas <i>RANK</i> gene rs1805034</span>, <i>OPG</i> gene rs3102735, <i>OPG</i> gene rs2073618, <i>OPG</i> gene rs3134069 polymorphisms were not related to RA susceptibility.
|
31209146 |
2019 |
rs1823375
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The subjects with G/G genotype of SNP rs1823375 were 1.77 times likely to develop RA than the subjects with C/C genotype.
|
30745815 |
2019 |
rs1870377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1870377 KDR variant has shown association with RA under the codominant (<i>p</i> = 0.02, OR = 1.76, 95% CI = 1.09-2.85) and recessive models (<i>p</i> = 0.019, OR = 1.53, 95% CI = 1.07-2.20).
|
31405022 |
2019 |
rs2071559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54).
|
31405022 |
2019 |
rs2277798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found the genotype distribution and allele frequency of rs2277798 were significantly associated with anti-CCP phenotype in the RA patients (χ<sup>2</sup> = 7.873, p=.020; χ<sup>2</sup> = 4.473, p=.034; respectively).
|
30822156 |
2019 |
rs2281089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis revealed that two SNPs (rs791588 and rs2281089) were significantly associated with a reduced RA risk in an allele and genetic model after stratification by gender or age (p < 0.05).
|
31134763 |
2019 |
rs2305948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54).
|
31405022 |
2019 |