rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The B cells percentage and mCD40 expression were similar between RA and CS (P > 0.05) and we did not find an association between these variables and the 1858C>T polymorphism.
|
30402903 |
2019 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Computational Molecular Phenotypic Analysis of PTPN22 (W620R), IL6R (D358A), and TYK2 (P1104A) Gene Mutations of Rheumatoid Arthritis.
|
30899276 |
2019 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
PTPN22 rs2476601 polymorphism frequency was higher in RA and UA vs the general population; however, this was significantly different only for RA vs control group (OR [95% CI] = 1.81 [1.10-3.02], P = 0.018.
|
30306282 |
2019 |
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Results showed that 1858 C/T PTPN22 SNP significantly (P = 0.007, OR = 2.321, 95% CI = 1.063-5.067) associated with RA.
|
31669381 |
2019 |
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASCAT |
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.
|
30891314 |
2019 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22<sup>R620W</sup>) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis.
|
30139951 |
2018 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Here we aimed to examine the associations of the PTPN22 R620W and R263Q polymorphisms with susceptibility to or protection against rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD) among Mexican patients.
|
28500376 |
2017 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We also found PTPN22 rs2476601 has no role in susceptibility to RA in Egyptian patients.
|
28424905 |
2017 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASCAT |
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
|
27193031 |
2017 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our study shows for the first time a marked down-regulation of PTPN22 expression in RA patients carrying the risk alleles of PTPN22 rs2488457 and rs2476601 compared to controls (p = 0.004 and p = 0.007, respectively).
|
28874816 |
2017 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
However, our meta-analysis confirms that the PTPN22 1858C/T</span> polymorphism is associated with RA susceptibility in Caucasians.
|
26763276 |
2016 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.
|
27166176 |
2016 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The presence of PTPN22 1858C→T polymorphism with HLA SE and autoantibodies increases risk of RA development and erosive disease.
|
27324632 |
2016 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The functional PTPN22 C1858T polymorphism was associated with an increased risk for RA in our study population.
|
26951256 |
2016 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our data not only establish a molecular link between PTPN22 and PAD-4, but also suggest that the C1858T SNP increases the risk of RA by enhancing protein citrullination and spontaneous formation of NETs.
|
26019128 |
2015 |
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals.
|
24665115 |
2015 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our meta-analysis demonstrated that PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms confers susceptibility to RA in total subjects and in major ethnic groups.
|
25963842 |
2015 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Considering that previous studies in other populations reported the T allele as the risk allele at this locus, the present study concluded that rs2476601 play no role in susceptibility to RA and other autoimmune diseases in Iranian population.
|
26547712 |
2015 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis.
|
25003765 |
2014 |
rs2476601
|
|
|
1.000 |
GeneticVariation |
GWASCAT |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
rs2476601
|
|
A |
1.000 |
GeneticVariation |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |