Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2476601
rs2476601
1.000 GeneticVariation GWASCAT A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. 27193031

2017

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population. 27166176

2017

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Association of PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms with rheumatoid arthritis: A meta-analysis update. 25963842

2016

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals. 24665115

2016

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population. 26763276

2016

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity. 25040563

2015

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Our data not only establish a molecular link between PTPN22 and PAD-4, but also suggest that the C1858T SNP increases the risk of RA by enhancing protein citrullination and spontaneous formation of NETs. 26019128

2015

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The strong association of the R620W variant of the PTPN22 gene with RA in Caucasians was not replicated since this variant was monomorphic in our study, but other SNP variants of the PTPN22 gene were also not associated with RA in black South Africans, suggesting that this locus does not play a major role in RA in this population. 25014791

2015

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheumatoid arthritis in Zahedan, Southeast Iran. 23350658

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis. 23370857

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis. 25003765

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation GWASCAT Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. 24449572

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis. 23637320

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation GWASDB Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. 24449572

2014

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. 22937072

2013

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants. 23450725

2013

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The +1858C/T single-nucleotide polymorphism (SNP) (rs2476601), in the exon 14 of the PTPN22 gene has been associated with susceptibility to RA in several population. 22743847

2013

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE RNA was extracted from positively selected CD56+, CD8+, and CD4+ mononuclear cells and the 'residual' cells from 12 RA patients heterozygous for the PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601). 22632125

2013

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2013

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE 1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis. 22209972

2012

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis. 22427951

2012

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population. 22704547

2012

dbSNP: rs2476601
rs2476601
1.000 GeneticVariation BEFREE Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region. 21965649

2012