|
rs2899642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the rs10192157 and rs2899642 mutations were documented with asthma disease.
|
31213409 |
2020 |
|
rs408223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GAC haplotype from rs4730125, rs6967330, and rs408223 was associated with pre-school current wheeze and school-age asthma.
|
31610042 |
2020 |
|
rs11602802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11603634 G allele was associated with increased expression of MUC5AC mRNA in bronchial epithelial brush samples via proxy SNP rs11602802; (p=2·50 × 10<sup>-5</sup>) and MUC5AC mRNA was increased in bronchial epithelial samples from patients with severe asthma (in two independent analyses, p=0·039 and p=0·022).
|
30552067 |
2019 |
|
rs12051168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The identified baseline FEV<sub>1</sub>/FVC ratio and rs12051168 association was meta-analyzed and replicated in three independent cohorts in which most participants with asthma also had confirmed AHR (combined weighted z-score P = .015) but not in cohorts without information about AHR.
|
31557467 |
2019 |
|
rs12186803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The KIF3A rs12186803 risk allele interacted with food sensitization to increase asthma ri</span>sk in children with eczema (P = 0.02).
|
30830718 |
2019 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported.
|
30209858 |
2019 |
|
rs1323556
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs1323556 was negatively associated with asthma in the additive model (OR 0.74, 95% CI 0.59-0.93) and in the dominant model (OR 0.71, 95% CI 0.53-0.74).
|
31126515 |
2019 |
|
rs1454197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of <i>MYH15</i> and may be functional variants conferring susceptibility to asthma.
|
30906771 |
2019 |
|
rs1575464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs1575464 was also negatively associated with asthma in two genetic models, additive (OR 0.77, 95% CI 0.62-0.96) and dominant (OR 0.73, 95% CI 0.55-0.97).
|
31126515 |
2019 |
|
rs1799768
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A PAI-1 functional polymorphism (rs1799768, 4G5G) was characterized in subjects with poorly controlled asthma enrolled in a randomized clinical trial of soy isoflavones (n = 265).
|
30707970 |
2019 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed that haplotype T-A-G-T (allele order: rs1800625, rs1800624, rs2070600, rs184003) was significantly associated with a reduced COPD risk (OR=0.32, 95% CI: 0.06-0.60), and haplotype T-A-A-G was significantly associated with a reduced asthma risk (OR=0.19, 95% CI: 0.04-0.96).
|
31141790 |
2019 |
|
rs1800625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed that haplotype T-A-G-T (allele order: rs1800625, rs1800624, rs2070600, rs184003) was significantly associated with a reduced COPD risk (OR=0.32, 95% CI: 0.06-0.60), and haplotype T-A-A-G was significantly associated with a reduced asthma risk (OR=0.19, 95% CI: 0.04-0.96).
|
31141790 |
2019 |
|
rs184003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed that haplotype T-A-G-T (allele order: rs1800625, rs1800624, rs2070600, rs184003) was significantly associated with a reduced COPD risk (OR=0.32, 95% CI: 0.06-0.60), and haplotype T-A-A-G was significantly associated with a reduced asthma risk (OR=0.19, 95% CI: 0.04-0.96).
|
31141790 |
2019 |
|
rs1974226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele of rs1974226 in <i>IL17A</i> was positively associated with asthma (OR: 1.37; 95% CI 1.02-1.82).
|
31168303 |
2019 |
|
rs2075820
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The homozygous AA genotype of rs2075820 was a risk factor for asthma (OR 2.39).
|
30874883 |
2019 |
|
rs213950
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of M470V polymorphism of CFTR gene with variability of clinical expression of asthma: Case-report study.
|
30268379 |
2019 |
|
rs2236648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> We analyzed four single nucleotide polymorphisms (SNPs): two in <i>GLCCI1</i> (rs37972 and rs37973), and two in <i>STIP1</i> (rs2236647 and rs2236648), which are genes associated with susceptibility to asthma and response to ICS in a Tunisian cohort.
|
31516081 |
2019 |
|
rs2280089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children.
|
31626088 |
2019 |
|
rs279548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the T allele of rs279548 was positively associated with asthma (OR: 1.30; 95% CI 1.02-1.64), atopy (OR: 1.62; 95% CI 1.05-2.50) and increased expression of the <i>IL17RC</i> in lung and whole blood tissues.
|
31168303 |
2019 |
|
rs2853209
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children.
|
31626088 |
2019 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only rs28929474, the most common pathologic SNP (Pi*Z) in the SERPINA1 gene, might be associated with a risk of developing school-age asthma without exhibiting preschool wheeze.
|
31298815 |
2019 |
|
rs3135499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs3135499 polymorphism of NOD2 gene and IFN-β may play a role in the pathogenesis of asthma.
|
30950247 |
2019 |
|
rs3827907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One variant, rs3827907, was significantly associated with ICS-mediated changes in asthma control in the discovery set (P = 7.79 × 10<sup>-8</sup>) and was jointly associated with asthma exacerbations in 3 validation cohorts (P = .023, P = .029, and P = .041).
|
30367910 |
2019 |
|
rs3918242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we found no significant association between -1562 C > T, rs3918242 polymorphism, and asthma susceptibility in any of the genetic model comparisons.
|
30931075 |
2019 |
|
rs4921581
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Children wildtype for rs4921581 had increasing asthma risk with increasing hair cotinine level, whereas those carrying the <i>NAT1</i> minor allele had an increased risk of asthma regardless of cotinine level.
|
31809667 |
2019 |