Source: ALL
Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE The association between methylation and asthma was independent of the genotype in rs7216389, rs4065275 and rs12603332. 25256354

2015

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE The results of this meta-analysis firmly established that genetic variation at the rs7216389 locus, which controls the expression of the ORMDL3, may be a major, independent predisposing factor for asthma in ethnically diverse populations. 25167772

2015

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation GWASDB Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. 24406073

2014

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE The haplotype (CAA) of rs7216389, rs4794820 and rs4065275 was associated with a lower risk of asthma susceptibility and a higher logPC(20). 22732088

2013

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE GMDR analyses revealed that rs7216389 in ORMDL3 and rs3756780 in ARG1 might interact for a risk of asthma. 22472724

2012

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389). 21337730

2011

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE Thus, the contribution of rs7216389-T to the development of asthma is unlikely to operate only through an impact on the expression of ORMDL3 or GSDMB genes. 20372189

2010

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE Asthma diagnosis was associated with rs11650680 and five other SNPs including rs7216389 (P = 0.019-0.034), whereas atopy was associated only with rs11650680 (P = 0.0004). 19175592

2009

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE A meta-analysis of five published studies on rs7216389 in nine populations gave an odds ratio for asthma of 1.44 (95% CI, 1.35-1.54, P < 0.00001). 19133921

2009

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation GWASDB Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. 17611496

2007

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation GWASCAT Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. 17611496

2007

dbSNP: rs4129267
rs4129267
0.820 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806

2018

dbSNP: rs1837253
rs1837253
0.820 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965

2017

dbSNP: rs1837253
rs1837253
0.820 GeneticVariation GWASCAT Identification of Four Novel Loci in Asthma in European American and African American Populations. 27611488

2017

dbSNP: rs2244012
rs2244012
0.820 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965

2017

dbSNP: rs1295686
rs1295686
0.820 GeneticVariation BEFREE We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. 26365633

2016

dbSNP: rs1837253
rs1837253
0.820 GeneticVariation BEFREE Surprisingly, rs1837253 (consistently associated with asthma) showed no correlation with TSLP expression levels. 26119467

2016

dbSNP: rs2244012
rs2244012
0.820 GeneticVariation BEFREE We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. 26365633

2016

dbSNP: rs1837253
rs1837253
0.820 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013

2014

dbSNP: rs2305480
rs2305480
0.820 GeneticVariation BEFREE GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic). 24066901

2014

dbSNP: rs1295686
rs1295686
0.820 GeneticVariation BEFREE There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. 23841068

2013

dbSNP: rs1295686
rs1295686
0.820 GeneticVariation GWASDB Genome-wide association study to identify genetic determinants of severe asthma. 22561531

2012

dbSNP: rs2305480
rs2305480
0.820 GeneticVariation BEFREE A 17q12 variant, rs2305480, was associated with asthma-like symptoms in preschool children, and this association was modified by smoke exposure already during fetal life, and in infancy. 22469062

2012