Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2431689
rs2431689
0.010 GeneticVariation BEFREE Rs17057846, rs1582417, and rs2431689 polymorphisms were associated with prognosis of astrocytoma, and rs1582417, rs17057846, and rs58747524 variants were associated with the survival rate in patients with low-grade glioma (I to II). 31513017

2020

dbSNP: rs12594
rs12594
0.010 GeneticVariation BEFREE Cox regression analysis shows that RYR2 rs12594 AA genotype and AG genotype were associated with OS of astrocytoma (AG genotype: HR = 1.62, 95% CI 1.04-2.53, p = 0.034; AA genotype: HR = 1.70, 95% CI 1.08-2.68, p = 0.021). 31440994

2019

dbSNP: rs16835904
rs16835904
0.010 GeneticVariation BEFREE Stratified analysis shows that RYR2 rs16835904 TC-TT genotype facilitated the risk of astrocytoma in male (OR = 1.93, 95% CI 1.15-3.24, p = 0.011). 31440994

2019

dbSNP: rs17522122
rs17522122
0.010 GeneticVariation BEFREE Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma. 31759389

2019

dbSNP: rs2378456
rs2378456
LPP
0.010 GeneticVariation BEFREE In recessive model, the patients with LPP rs2378456 CC genotype increased the risk of astrocytoma (OR = 1.43, 95% CI 1.01-2.02, p = 0.042). 31440994

2019

dbSNP: rs4261436
rs4261436
0.010 GeneticVariation BEFREE Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma. 31759389

2019

dbSNP: rs7115578
rs7115578
0.010 GeneticVariation BEFREE Additionally, rs7115578 AG genotype represented a poorer prognosis of glioma (HR = 1.24, P=0.033) and astrocytoma (log-rank P=0.037, HR = 1.31, P=0.036). 31652449

2019

dbSNP: rs5050
rs5050
AGT
0.010 GeneticVariation BEFREE Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma. 30383794

2018

dbSNP: rs1040177874
rs1040177874
0.010 GeneticVariation BEFREE Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 27460417

2016

dbSNP: rs1801275
rs1801275
0.010 GeneticVariation BEFREE Univariate analysis showed that IL4R rs1801275 was significantly associated with overall survival of glioma and astrocytoma</span> patients (P < 0.05). 27495027

2016

dbSNP: rs1870377
rs1870377
KDR
0.010 GeneticVariation BEFREE However, individuals with mutant allele A and genotype TA + AA of rs1870377 showed a protective effect against astrocytomas. 26081139

2016

dbSNP: rs2071559
rs2071559
KDR
0.010 GeneticVariation BEFREE Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers. 26081139

2016

dbSNP: rs2271338
rs2271338
0.010 GeneticVariation BEFREE A three-variant ADHD risk haplotype in evolutionary conserved region 47, formed by rs17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytoma cells (p<sub>Bonferroni</sub> < .0001). 27692237

2016

dbSNP: rs2305948
rs2305948
KDR
0.010 GeneticVariation BEFREE Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers. 26081139

2016

dbSNP: rs55819519
rs55819519
0.010 GeneticVariation BEFREE No IDH1-R132H mutation was detected in 2 of 2 (0%) astrocytomas by immunohistochemistry. 26990854

2016

dbSNP: rs9288516
rs9288516
0.010 GeneticVariation BEFREE The SNP (rs9288516) in XRCC5 (HR: 1.69, 95%CI: 1.04 - 2.77, p = 0.049), surgical approach (HR: 0.61, 95%CI: 0.43 - 0.88, p = 0.003) and chemotherapy (HR: 0.71, 95%CI: 0.50 - 0.99, p = 0.029) were associated with astrocytoma prognosis. 27852033

2016

dbSNP: rs4809324
rs4809324
0.010 GeneticVariation BEFREE Moreover, the stratified analyses showed a decreased risk of astrocytoma associated with RTEL1 rs6089953, rs6010620 and rs2297440 (p trend = 0.022, p trend = 0.042, p trend = 0.029, respectively) as well as an increased risk of this subtype associated with RTEL1 rs4809324 (p trend = 0.033). 26014354

2015

dbSNP: rs6089953
rs6089953
0.010 GeneticVariation BEFREE Moreover, the stratified analyses showed a decreased risk of astrocytoma associated with RTEL1 rs6089953, rs6010620 and rs2297440 (p trend = 0.022, p trend = 0.042, p trend = 0.029, respectively) as well as an increased risk of this subtype associated with RTEL1 rs4809324 (p trend = 0.033). 26014354

2015

dbSNP: rs71305152
rs71305152
0.010 GeneticVariation BEFREE In the astrocytoma subtype, higher ZFPM2 expression was also correlated with the rs71305152 heterozygous genotype (P = 0.028). 26207917

2015

dbSNP: rs3745601
rs3745601
0.010 GeneticVariation BEFREE We investigated receptor functionality of the P2Y11 A87T mutant using HEK293 and 1321N1 astrocytoma cells. 24524250

2014

dbSNP: rs137852972
rs137852972
0.010 GeneticVariation BEFREE In this study, we show that expression of seipin N-glycosylation mutant N88S led to decreased triglyceride (TG) content in astrocytoma and motor neuron cell lines. 23250914

2013

dbSNP: rs2853676
rs2853676
0.010 GeneticVariation BEFREE In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk. 23812731

2013

dbSNP: rs6010620
rs6010620
0.010 GeneticVariation BEFREE In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk. 23812731

2013

dbSNP: rs58064122
rs58064122
0.010 GeneticVariation BEFREE On the basis of the protective role shown by both these small heat shock proteins (sHSPs), and on the already well established neuroprotective effects of curcumin in several diseases, we have investigated the effects of this compound in an in vitro model of Alexander disease, consisting in U251-MG astrocytoma cells transiently transfected with a construct encoding for GFAP carrying the p.R239C mutation in frame with the reporter green fluorescent protein (GFP). 22705585

2012

dbSNP: rs861539
rs861539
0.010 GeneticVariation BEFREE We suggest that XRCC3 Thr241Met polymorphism is involved in susceptibility for developing astrocytomas and glioblastomas. 22370935

2012