Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2271338
rs2271338
0.010 GeneticVariation BEFREE A three-variant ADHD risk haplotype in evolutionary conserved region 47, formed by rs17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytoma cells (p<sub>Bonferroni</sub> < .0001). 27692237

2016

dbSNP: rs5050
rs5050
AGT
0.010 GeneticVariation BEFREE Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma. 30383794

2018

dbSNP: rs17522122
rs17522122
0.010 GeneticVariation BEFREE Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma. 31759389

2019

dbSNP: rs4261436
rs4261436
0.010 GeneticVariation BEFREE Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma. 31759389

2019

dbSNP: rs1801516
rs1801516
ATM
0.010 GeneticVariation BEFREE We propose the three-hit hypothesis as a triangle initiators includes D1853N as a first predisposing hit, IVS 38- 63T --> A as a second hit deriving from the first somatic evolution before differentiation and IVS 38- 30 A --> G as a third hit through the development of an astrocytoma. 18465141

2008

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE BRAF(V600E) mutation seems to define a subset of malignant astrocytomas in children, in which there is frequent concomitant homozygous deletion of CDKN2A (five of seven cases). 20068183

2010

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE BRAF V600E mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells. 24354918

2014

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE Thus BRAF V600E mutation is common in desmoplastic non-infantile astrocytoma/ganglioglioma, but does not affect the prognosis. 29902580

2018

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE The BRAF(V600E) inhibitor PLX4720 significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells. 22586120

2012

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE An institutional cohort of 105 brain tumors (51 dysembryoplastic neuroepithelial tumors (DNTs), 14 subependymal giant cell astrocytomas (SEGAs), 12 glioblastoma with neuronal marker expression (GBM-N), and 28 pleomorphic xanthoastrocytomas (PXAs)) from 100 patients were investigated for the presence of BRAF(V600E) by direct sequencing. 25346165

2015

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE Similar to previously reported findings on E-GBM associated with low-grade glioma, this case suggested that low-grade astrocytic glioma with BRAF V600E mutation progressed to E-GBM. 26602910

2016

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE With regard to implications for therapy, our results support evaluation of BRAF(V600E)-specific inhibitors for treating BRAF(V600E) MA patients. 22038996

2011

dbSNP: rs113488022
rs113488022
0.080 GeneticVariation BEFREE In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma. 30972500

2019

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma. 30972500

2019

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE Similar to previously reported findings on E-GBM associated with low-grade glioma, this case suggested that low-grade astrocytic glioma with BRAF V600E mutation progressed to E-GBM. 26602910

2016

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE An institutional cohort of 105 brain tumors (51 dysembryoplastic neuroepithelial tumors (DNTs), 14 subependymal giant cell astrocytomas (SEGAs), 12 glioblastoma with neuronal marker expression (GBM-N), and 28 pleomorphic xanthoastrocytomas (PXAs)) from 100 patients were investigated for the presence of BRAF(V600E) by direct sequencing. 25346165

2015

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE BRAF(V600E) mutation seems to define a subset of malignant astrocytomas in children, in which there is frequent concomitant homozygous deletion of CDKN2A (five of seven cases). 20068183

2010

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE The BRAF(V600E) inhibitor PLX4720 significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells. 22586120

2012

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE Thus BRAF V600E mutation is common in desmoplastic non-infantile astrocytoma/ganglioglioma, but does not affect the prognosis. 29902580

2018

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE BRAF V600E mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells. 24354918

2014

dbSNP: rs121913377
rs121913377
0.080 GeneticVariation BEFREE With regard to implications for therapy, our results support evaluation of BRAF(V600E)-specific inhibitors for treating BRAF(V600E) MA patients. 22038996

2011

dbSNP: rs137852972
rs137852972
0.010 GeneticVariation BEFREE In this study, we show that expression of seipin N-glycosylation mutant N88S led to decreased triglyceride (TG) content in astrocytoma and motor neuron cell lines. 23250914

2013

dbSNP: rs773442580
rs773442580
EGF
0.010 GeneticVariation BEFREE In this study, we investigated whether stable expression of an activated Ki-Ras oncogenic mutant (G12V) in human astrocytoma cells leads to constitutive activation of the MAP kinase pathway and how this may influence cellular proliferation and signaling by epidermal growth factor (EGF) receptor. 9863009

1999

dbSNP: rs1057519897
rs1057519897
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

dbSNP: rs1057519898
rs1057519898
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016