|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These findings indicated that TLR4 Asp299Gly polymorphism may not play a role in AS development.
|
22857799 |
2012 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In summary, results in our study do not support the hypothesis that the rs4986790 (+896A>G, Asp299Gly) TLR4 variant may influence predisposition for subclinical atherosclerosis and clinically evident CV disease in RA patients.
|
22360682 |
2012 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The G allele of the Toll-like receptor 4 (TLR-4) gene Asp299Gly polymorphism has been previously associated with decreased development of atherosclerosis and with lower risk of myocardial infractions.
|
17996871 |
2008 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To explore a potential atheroprotective effect, we studied the association between the Asp299Gly polymorphism and atherosclerosis in hypertensive patients undergoing angiography for suspected renovascular disease.
|
17587646 |
2007 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-4 gene in atherosclerosis.
|
17101559 |
2006 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We examined toll-like receptor 4 (TLR4) as a candidate gene for AMD susceptibility because: (i) the TLR4 gene is located on chromosome 9q32-33, a region exhibiting evidence of linkage to AMD in three independent reports; (ii) the TLR4-D299G variant is associated with reduced risk of atherosclerosis, a chronic inflammatory disease with subendothelial accumulation; (iii) the TLR4 is not only a key mediator of proinflammatory signaling pathways but also linked to regulation of cholesterol efflux and (iv) the TLR4 participates in phagocytosis of photoreceptor outer segments by the RPE.
|
15829498 |
2005 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The presence of the Asp299Gly allele of the TLR4 gene does not seem to exert a major influence on the progression of atherosclerosis in patients with FH.
|
14764071 |
2004 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were genotyped for the TLR4 Asp299Gly polymorphism using the tetra-primer PCR method.
|
12957699 |
2003 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is associated with a decreased risk of atherosclerosis.
|
12124407 |
2002 |