Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10033464
rs10033464
0.900 GeneticVariation BEFREE Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF. 31393025

2019

dbSNP: rs10033464
rs10033464
0.900 GeneticVariation BEFREE In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence. 31169720

2019

dbSNP: rs2106261
rs2106261
0.900 GeneticVariation BEFREE The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [<i>PITX2</i>] and rs2106261 at chromosome 16q22 [<i>ZFHX3</i>]), which showed modest associations with AF recurrence. 30808078

2019

dbSNP: rs2106261
rs2106261
0.900 GeneticVariation BEFREE Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis. 31169720

2019

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence. 31169720

2019

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE We aimed to assess whether SNPs previously associated with lone AF (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P-wave abnormalities. 31152482

2019

dbSNP: rs10033464
rs10033464
0.900 GeneticVariation BEFREE Among the 8 AF risk SNPs genotyped, only rs10033464 SNP at chromosome (chr) 4q25 (near PITX2) was significantly associated with development of AF after multiple risk factor adjustment and multiple testing (adj. odds ratio [OR] 2.27, 95% confidence interval [CI] 1.31-3.94; P = 3.3 x 10-3). 29624624

2018

dbSNP: rs10033464
rs10033464
0.900 GeneticVariation BEFREE After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence. 29240960

2018

dbSNP: rs2106261
rs2106261
0.900 GeneticVariation BEFREE The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation. 30180182

2018

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE Polymorphisms in PITX2 (rs2200733) and IL6 (rs1800795) are associated with postoperative atrial fibrillation in adults but have not been studied in CHD. 29800783

2018

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence. 29240960

2018

dbSNP: rs10033464
rs10033464
0.900 GeneticVariation BEFREE In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF. 27346453

2017

dbSNP: rs2106261
rs2106261
T 0.900 GeneticVariation GWASCAT Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. 28416822

2017

dbSNP: rs2106261
rs2106261
T 0.900 GeneticVariation GWASCAT Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci. 28460022

2017

dbSNP: rs2106261
rs2106261
T 0.900 GeneticVariation GWASCAT Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. 28416818

2017

dbSNP: rs2106261
rs2106261
0.900 GeneticVariation BEFREE We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes. 28007413

2017

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE rs2200733 risk allele at the 4q25 predicted impaired clinical response to catheter ablation for AF in Chinese Han population. 27843048

2017

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF. 27346453

2017

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE Our results suggest that SNP rs2200733 confers a significant risk of AF in the Greek population, providing further support to the previously reported association between AF and rs2200733 polymorphism on chromosome 4q25. 26021244

2016

dbSNP: rs10033464
rs10033464
0.900 GeneticVariation BEFREE Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF). 25684755

2015

dbSNP: rs2106261
rs2106261
0.900 GeneticVariation BEFREE Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1. 26267381

2015

dbSNP: rs2106261
rs2106261
0.900 GeneticVariation BEFREE The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). 26272656

2015

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). 26272656

2015

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1. 26267381

2015

dbSNP: rs2200733
rs2200733
0.900 GeneticVariation BEFREE Among the 3 genetic loci most strongly associated with AF, the chromosome 4q25 SNP rs2200733 is significantly associated with recurrence of atrial arrhythmias after catheter ablation for AF. 25684755

2015