|
rs10454134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A higher frequency of both the rs10454134 AG genotypes (p = 0.008, OR = 1.413, 95% CI = 1.094-1.826) and a lower GG genotype frequency (p = 0.003, OR = 0.630, 95% CI = 0.465-0.854) were found in BD patients compared to the controls in the first stage.
|
31223615 |
2019 |
|
rs10515746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behçet disease and 200 healthy controls.
|
31644615 |
2019 |
|
rs12119179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only a systematic review was conducted for rs12119179, rs11209032, and rs12141431, owing to the lack of sufficient data.<b>Conclusion</b>: This meta-analysis indicated that rs17375018 (G/A) and rs924080 (T/C) were associated with BD susceptibility.
|
31814470 |
2019 |
|
rs1342326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with BD exhibited a significantly higher prevalence of the T/G genotype of rs1342326</span> polymorphism compared with the control group.
|
30447310 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
rs4073153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed a significant decrease of the frequency of a <i>CARD9</i> gene haplotype CGCCA (rs4077515, rs11145769, rs59902911, rs9411205, rs4073153) in BD when compared to healthy controls (<i>Pc </i>= 0.012, OR = 0.585, 95%CI = 0.409 ~ 0.837).
|
31671006 |
2019 |
|
rs4936742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population.
|
30289285 |
2019 |
|
rs7528684
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the alleles revealed a significantly lower frequency of the A allele at the -169 site (rs7528684) in BD patients compared with that in controls (<i>P</i>=0.000, 66.4% versus 82%, χ<sup>2</sup>= 30.23).
|
31341856 |
2019 |
|
rs10094579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rates of the rs1800872 A allele was statistically lower in the control group compared with BD patients (p = 0.0315 and OR = 1.90 (1.05-3.42)).
|
29294320 |
2018 |
|
rs224127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs30187
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs30187 showed the strongest association with BD in the recessive genotype model of the risk T allele in HLA-B*51 carriers.
|
30514861 |
2018 |
|
rs428888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings demonstrate that FCGR3A/rs428888 confers genetic susceptibility for ocular BD in Han Chinese.
|
29555961 |
2018 |
|
rs7234029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study shows that a PTPN2-rs7234029 polymorphism is associated with ocular BD and is strongly influenced by gender.
|
29502070 |
2018 |
|
rs913678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD i</span>n an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs9316059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
|
29907633 |
2018 |
|
rs1234313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele and AA genotype frequencies of <i>TNFSF4</i>/rs1234313 were significantly increased, and the GG genotype frequency of rs1234313 was decreased in subjects with BD.
|
29285231 |
2017 |
|
rs2903908
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study represents for the first time that the <i>NCOA5</i> rs2903908 polymorphism seemed to be linked to BD susceptibility and clinical findings.
|
28694762 |
2017 |
|
rs3914501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GWAS and validation studies showed intestinal BD-specific associations with an NAALADL2 gene locus (rs3914501, P = 3.8 × 10<sup>-4</sup>) and a YIPF7 gene locus (rs6838327, P = 3.5 × 10<sup>-4</sup>).
|
28045058 |
2017 |
|
rs4246905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly lower frequencies of the C allele and the CC genotype and higher frequencies of the TT and CT genotypes of <i>TNFSF15</i>/rs4246905 were observed in BD patients.
|
29285231 |
2017 |
|
rs7028891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A decreased frequency of the A allele of <i>TNFSF8</i>/rs7028891 was observed in BD patients.
|
29285231 |
2017 |
|
rs9517723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that enhanced UBAC2 expression associated with the homozygous risk allele (TT) of rs9517723 could induce overactivation of ubiquitination-related pathway, resulting in the development of ocular and CNS lesions in BD.
|
28389674 |
2017 |
|
rs1048709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, subgroup analyses showed that CFB-rs1048709 was specifically associated with VKH, where significantly higher frequencies of A allele and AA homozygosity were observed in VKH patients compared with controls (P corr = 0.025 and P corr = 0.035, respectively), whereas none of these five SNPs was associated with IU or BD.
|
26671509 |
2016 |
|
rs11230563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significantly higher frequency of the CT genotype, and a lower frequency of the CC genotype and C allele of CD6 rs11230563 were observed in BD as compared with controls.
|
27108704 |
2016 |
|
rs11642873
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs near IRF8 were associated with BD (for rs17445836 GG genotype, Pc = 9.56 × 10(-8), OR = 2.044; for rs11642873 AA genotype, Pc = 9.24 × 10(-7), OR = 1.776).
|
26794091 |
2016 |