rs1006737
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
|
18711365 |
2008 |
rs1006737
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
|
18711365 |
2008 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data demonstrate that rs1006737 or genetic variants in linkage disequilibrium with it are functional in the human brain and provide a neurogenetic risk mechanism for bipolar disorder backed by genome-wide evidence.
|
20679588 |
2010 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including our BD sample (N=1868) studied within the Wellcome Trust Case Control Consortium.
|
19621016 |
2010 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The polymorphism rs1006737 within the CACNA1C gene is associated with increased risk for bipolar disorder (BD) and variations in brain morphology and function of subcortical regions.
|
21292451 |
2011 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
|
20351715 |
2011 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using three samples, including healthy controls, patients with SCZ, and patients currently in manic episodes of BP, this study tested the association between the SNP rs1006737 and spatial working memory as measured by an N-back task and a dot pattern expectancy (DPX) task.
|
22012475 |
2012 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data demonstrate that the effect of CACNA1C rs1006737 and ANK3 rs10994336 (or genetic variants in linkage disequilibrium) on the brain converges on the neural circuitry involved in affect processing and provides a mechanism linking BD to genome-wide genetic risk variants.
|
24108394 |
2013 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although we were not able to replicate findings of association between individual CACNA1C SNPs rs7297582 and rs1006737 and BP, we were able to replicate the GWAS signal reported for CACNA1C through a haplotype analysis that encompassed these previously reported significant SNPs.
|
23437964 |
2013 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)].
|
23406546 |
2013 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder</span> (BD) and schizophrenia (SZ) pathology.
|
23437284 |
2013 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
|
23070075 |
2013 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression.
|
23979604 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder.
|
23404764 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity.
|
25976633 |
2015 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study further supports the association of SNP rs1006737 with BD-I and suggests that CACNA1C SNP rs1006737 and Bcl-2 SNP rs956572, or specific causal variants in LD with these proxies, act independently to increase risk and ICDH in BD-I.
|
25843436 |
2016 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau/total tau ratio in patients with bipolar disorder, thus linking variation in the CACNA1C gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder.
|
26541689 |
2016 |