Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the ZNF804A gene. 27790829

2017

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau/total tau ratio in patients with bipolar disorder, thus linking variation in the CACNA1C gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder. 26541689

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology. 26048451

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity. 25976633

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing. 24411473

2015

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASCAT Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982

2015

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression. 23979604

2015

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. 25290268

2015

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Our data demonstrate that the effect of CACNA1C rs1006737 and ANK3 rs10994336 (or genetic variants in linkage disequilibrium) on the brain converges on the neural circuitry involved in affect processing and provides a mechanism linking BD to genome-wide genetic risk variants. 24108394

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE A total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)]. 23406546

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder. 23404764

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASDB Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. 23070075

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE   Although we were not able to replicate findings of association between individual CACNA1C SNPs rs7297582 and rs1006737 and BP, we were able to replicate the GWAS signal reported for CACNA1C through a haplotype analysis that encompassed these previously reported significant SNPs. 23437964

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE We performed a functional Magnetic Resonance Imaging (fMRI) study in a sample of BD and SZ cases and healthy controls to test for altered amygdala activity in carriers of the rs1006737 risk allele (AA/AG), and to investigate if there were differences across the diagnostic groups. 23437284

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317

2012

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Using three samples, including healthy controls, patients with SCZ, and patients currently in manic episodes of BP, this study tested the association between the SNP rs1006737 and spatial working memory as measured by an N-back task and a dot pattern expectancy (DPX) task. 22012475

2012

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE An effect on gray matter volume of the bipolar disorder-associated SNP rs1006737, as reported earlier in a sample of 77 healthy adults, could not be confirmed. 20638048

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE In the present study, we did not find evidence for association between the bipolar disorder risk polymorphisms rs10994336 in the ANK3 gene and rs1006737 in the CACNA1C gene in migraine. 21395576

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The polymorphism rs1006737 within the CACNA1C gene is associated with increased risk for bipolar disorder (BD) and variations in brain morphology and function of subcortical regions. 21292451

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including our BD sample (N=1868) studied within the Wellcome Trust Case Control Consortium. 19621016

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASDB Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression. 21676128

2011