|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs10994336 and rs9804190 in ANK3 and rs1006737 in CACNA1C have emerged as the most highly replicated SNPs significantly associated with BD.
|
29684488 |
2018 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, a significant association was found between BD and rs10994336 (OR=1.18; 95% confidence interval: 1.06-1.31; P=0.0027) as well as rs1938526 (OR=1.16; 95% confidence interval: 1.06-1.28; P=0.0016).
|
29068871 |
2017 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The haplotype analysis results suggest that ANK3 variants rs1938526 and rs10994336 may confer susceptibility for BD in the Korean population.
|
28079488 |
2017 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A polymorphism (rs10994336) within the ANK3 gene has been associated with BD in at least three genome-wide association studies of BD [McGuffin et al., 2003; Kieseppä, 2004; Edvardsen et al., 2008].
|
27177275 |
2016 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The intronic single-nucleotide polymorphism rs10994336 of the ankyrin 3 gene (ANK3 ) is one of the genome-wide supported risk variants for bipolar disorder (BD), and the T-allele of rs10761482 is also reported to have relevance to BD.
|
27488254 |
2016 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We examined the effect of BD-risk polymorphisms at rs10994336 and rs9804190 on the working memory (WM) circuit using functional magnetic resonance imaging (fMRI) data obtained from euthymic patients with BD (n = 41), their psychiatrically healthy first-degree relatives (n = 25) and unrelated individuals without personal or family history of psychiatric disorders (n = 46) while performing the N-back task.
|
25711502 |
2015 |
|
rs10994336
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study reveals two new risk loci for bipolar disorder.
|
24618891 |
2014 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data demonstrate that the effect of CACNA1C rs1006737 and ANK3 rs10994336 (or genetic variants in linkage disequilibrium) on the brain converges on the neural circuitry involved in affect processing and provides a mechanism linking BD to genome-wide genetic risk variants.
|
24108394 |
2013 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Independent genome-wide association studies have implicated a common single nucleotide polymorphism within the ANK3 gene (rs10994336) in bipolar disorder (BD) susceptibility, thus establishing rs10994336 marker as a strong candidate predisposing genetic factor for BD.
|
22498896 |
2012 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two meta analyses reported another SNP rs10994336 in ANK3 gene confers risk to bipolar disorder (BD).
|
23109352 |
2012 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found no association of rs9804190 and rs10994336 with bipolar disorder, unipolar depression or schizophrenia.
|
21702894 |
2011 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide genetic studies have reported a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3.
|
21304963 |
2011 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105).
|
21972176 |
2011 |
|
rs10994336
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
rs10994336
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G).
|
18711365 |
2008 |
|
rs10994336
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G).
|
18711365 |
2008 |