|
rs12921862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>AXIN1</i> gene polymorphisms might implicate in BC risk, and rs12921862 could be a potential forecasting factor for prognosis of BC patients.
|
31143301 |
2019 |
|
rs138377917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
|
rs1805105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data revealed that three tag SNPs were associated with an increased risk of BC (rs12921862: <i>P</i> < 0.001, OR (95%CI) = 4.61 (3.13-6.81); rs1805105: <i>P</i> = 0.046, OR (95%CI) = 1.35 (1.00-1.82); and rs370681: <i>P</i> = 0.004, OR (95%CI) = 1.56 (1.15-2.10)).
|
31143301 |
2019 |
|
rs2067079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18-2.56), adjusted P value = 0.02).
|
31250374 |
2019 |
|
rs2073859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PCR-Restriction Fragment Length Polymorphism (RFLP) was used to genotype LIMK2 SNP rs2073859 and multivariate logistic regression applied to assess the relationship between allele frequency and clinical features in 139 BC patients.
|
30006972 |
2019 |
|
rs2278329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with bladder cancer and controls did not differ significantly in terms of genotype frequencies and allele frequency distribution of rs2278329 (P = 0.77, OR = 0.97) and rs2292016 (P = 0.39, OR = 1.20) respectively.
|
30755233 |
2019 |
|
rs2292016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with bladder cancer and controls did not differ significantly in terms of genotype frequencies and allele frequency distribution of rs2278329 (P = 0.77, OR = 0.97) and rs2292016 (P = 0.39, OR = 1.20) respectively.
|
30755233 |
2019 |
|
rs2293607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At the end of the study, we suggested that there may exist an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population.
|
30120764 |
2019 |
|
rs2735971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between lncRNA H19 (rs217727, rs2735971 and rs3024270) polymorphisms and the risk of bladder cancer in Chinese population.
|
29595036 |
2019 |
|
rs2976391
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
|
rs2976392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
|
rs3024270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between lncRNA H19 (rs217727, rs2735971 and rs3024270) polymorphisms and the risk of bladder cancer in Chinese population.
|
29595036 |
2019 |
|
rs370681
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data revealed that three tag SNPs were associated with an increased risk of BC (rs12921862: <i>P</i> < 0.001, OR (95%CI) = 4.61 (3.13-6.81); rs1805105: <i>P</i> = 0.046, OR (95%CI) = 1.35 (1.00-1.82); and rs370681: <i>P</i> = 0.004, OR (95%CI) = 1.56 (1.15-2.10)).
|
31143301 |
2019 |
|
rs4143815
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C > G might increase the susceptibility to gastric cancer (G vs. C: OR = 1.842, 95% CI: 1.403-2.418, p < 0.001) and bladder cancer (G vs. C: OR = 2.015, 95% CI: 1.556-2.608, p < 0.001), and genotype GG carriers of PD-L1 rs4143815 C > G might have higher risks of HCC (GG vs. CG + CC: OR = 2.226 95% CI: 1.562-3.172, p < 0.001).
|
30552042 |
2019 |
|
rs6790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18-2.56), adjusted P value = 0.02).
|
31250374 |
2019 |
|
rs8444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that LASS2-3'-UTR r</span>s8444 C>T polymorphism was significantly associated with the individual risk and the poor overall survival of bladder cancer, suggesting that rs8444 TT genotype maybe act as an independent risk factor of susceptibility and clinical prognosis for bladder cancer in Chinese population.
|
31577563 |
2019 |
|
rs9297976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
|
rs11191438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AS3MT rs11191438 (C > G) G/G genotype, AS3MT rs10748835 (A > G) G/G genotype, and AS3MT rs1046778 (C > T) T/T genotype were found to be related to BC risk, where the odds ratio (OR) (95% CI) was 0.50 (0.31-0.82), 0.49 (0.30-0.79), and 0.54 (0.36-0.80), respectively.
|
29669044 |
2018 |
|
rs11191454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphisms of AS3MT rs11191438, AS3MT rs10748835, and AS3MT rs1046778 were related to the risk of BC and UTUC, while the polymorphisms of AS3MT rs3740393, AS3MT rs11191453, and AS3MT rs11191454 were associated with arsenic methylation capacity.
|
29859237 |
2018 |
|
rs1130214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the other examined polymorphisms (<i>AKT1</i> rs1130214, <i>AKT1</i> rs3730358, <i>mTOR</i> rs1883965) revealed significant association with BC.
|
29383014 |
2018 |
|
rs1130233
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that <i>PIK3CA</i> rs6443624, <i>AKT1</i> rs2498801, <i>AKT1</i> rs1130233, as well <i>mTOR</i> rs2295080 polymorphism may be related to bladder cancer development in a sample of Iranian population.
|
29383014 |
2018 |
|
rs13278062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP), -397G > T (rs13278062) polymorphism, in the promoter of Death Receptor 4 (DR4) had been reported to be associated with a significantly increased risk for bladder cancer.
|
29446085 |
2018 |
|
rs1428779969
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LPXN may facilitate bladder cancer progression by upregulating the expression of S100P via PI3K/AKT pathway.
|
29975926 |
2018 |
|
rs1883965
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the other examined polymorphisms (<i>AKT1</i> rs1130214, <i>AKT1</i> rs3730358, <i>mTOR</i> rs1883965) revealed significant association with BC.
|
29383014 |
2018 |
|
rs2295080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, mTOR rs2295080 variant notably increased the risk of BC (OR=2.25, 95 % CI=1.50-3.38, p<0.0001, GT vs GG; OR=4.75, 95 % CI=2.80-8.06, p<0.0001, TT vs GG; OR=3.10, 95 % CI=2.34-4.10, p<0.0001, T vs G).
|
29383014 |
2018 |