|
rs10094872
|
|
T |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.
|
24861552 |
2014 |
|
rs1014971
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.
|
20972438 |
2010 |
|
rs1014971
|
|
T |
0.720 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
|
rs1014971
|
|
|
0.720 |
GeneticVariation |
BEFREE |
SNP rs1014971 was associated with bladder cancer risk, increased APOBEC3B expression, and enrichment with APOBEC-signature mutations in bladder tumors.
|
27643540 |
2016 |
|
rs1014971
|
|
|
0.720 |
GeneticVariation |
GWASDB |
In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.
|
20972438 |
2010 |
|
rs10234749
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes).
|
17557904 |
2007 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs1041983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate whether the slow acetylator genotype is a risk factor for development of bladder cancer following schistosomal infection of the urinary tract, the authors determined the frequencies of 3 common polymorphisms in the NAT2 gene (341T>C, 590G>A, and 282C>T), which are associated with impaired acetylation activity, in control subjects (n=61; mean age 34.3+/-9.2 years) and in schistosomiasis-associated bladder cancer patients (n=55; 52+/-10.9 years) from the Egyptian population.
|
15905799 |
2005 |
|
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Because of its functional role and published data showing the influence of Arg213His polymorphism on the risk of some cancers, we hypothesized that the His(213) allele of the SULT1A1 gene may modify bladder cancer risk.
|
14643027 |
2003 |
|
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings have suggested that the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC.
|
28589969 |
2017 |
|
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis indicated that SULT1A1 Arg213His polymorphism is associated with bladder cancer risk.
|
25194687 |
2014 |
|
rs1042028
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No significant association was found between the SULT1A1 Arg213His</span> polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR = 1.218, 95 % CI = 1.067-1.392, P = 0.0044) under the recessive model.
|
24763827 |
2014 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We have reported previously that the TP53 codon72 polymorphism (rs1042522) is associated with the incidence and invasiveness of bladder cancer in a Han Chinese population.
|
22178231 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
P53 Arg72Pro polymorphism and bladder cancer risk--meta-analysis evidence for a link in Asians but not Caucasians.
|
22901221 |
2012 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Subgroup analyses by ethnicity showed that TP53 Arg72Pro polymorphism contributed to bladder cancer</span> risk in East Asians in three genetic models (For Pro vs. Arg, Fixed-effects OR 1.18, 95 % CI 1.05-1.32; For ProPro vs. ArgArg, Fixed-effects OR 1.40, 95 % CI 1.11-1.77; For ProPro vs. ArgPro/ArgArg, Fixed-effects OR 1.32, 95 % CI 1.07-1.62).
|
23184052 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Thus, it is evident from our study that Arg72Pro SNP is implicated in bladder cancer, and that the rare, proline-related allele is connected with higher susceptibility to bladder cancer.
|
21156242 |
2010 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk.
|
20630574 |
2010 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of bladder cancer in Asians.
|
23073555 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder cancer and cervical cancer.
|
26123760 |
2015 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the susceptibility to bladder cancer.
|
19523860 |
2011 |
|
rs1043210477
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The GPX1 Pro/Leu genotype may significantly increase the risk of bladder cancer and the increased risk may be modified by the Ala-9Val MnSOD polymorphism.
|
15247771 |
2004 |
|
rs1043210477
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This systematic review and meta-analysis demonstrated that the GPX1 Pro198Leu polymorphism significantly increased susceptibility to bladder cancer, while the MnSOD Ala-9Val polymorphism was not associated with bladder cancer risk.
|
24037914 |
2014 |
|
rs1046428
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations between THMs and bladder cancer were stronger among subjects who were GSTT1 +/+ or +/- versus GSTT1 null (P(interaction) = 0.021), GSTZ1 rs1046428 CT/TT versus CC (P(interaction) = 0.018), or CYP2E1 rs2031920 CC versus CT/TT (P(interaction) = 0.035).
|
20675267 |
2010 |
|
rs1046778
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphisms of AS3MT rs11191438, AS3MT rs10748835, and AS3MT rs1046778 were related to the risk of BC and UTUC, while the polymorphisms of AS3MT rs3740393, AS3MT rs11191453, and AS3MT rs11191454 were associated with arsenic methylation capacity.
|
29859237 |
2018 |
|
rs1046778
|
|
|
0.020 |
GeneticVariation |
BEFREE |
High MMA%, low DMA% and AS3MT rs1046778 C/C + C/T genotype predicted a significantly higher risk of BC according to stepwise multiple logistic regression analyses.
|
29669044 |
2018 |