Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE The BRAF V600E mutation and KIAA1549-BRAF fusion are alterations found in several brain tumors and show a distinct prognostic impact in some entities. 31181803

2019

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Epithelioid glioblastoma is a recognized glioblastoma variant, recently added to the World Health Organization brain tumor classification, with similar prognosis as the classic variant and B-Raf V600E mutations in 50% of the cases. 31258848

2019

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Emerging evidence support the effectiveness of targeted therapies for brain tumors with BRAF V600E mutation. 31345255

2019

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Efficacy of BRAF V600E targeted therapies in brain tumors harboring the mutation has been shown in several case reports and is currently being studied in larger clinical trials. 29380516

2018

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE This report presents 2 cases of malignant brain tumors with <i>BRAF</i> V600E mutations that were resistant to radiation and temozolomide, and reports on their response to targeted treatment with the BRAF and MEK inhibitors dabrafenib and trametinib. 29632053

2018

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Pleomorphic xanthoastrocytoma is a rare brain tumor with unique high frequency of BRAF V600E mutation which is plausible for targeted therapy. 29200156

2018

dbSNP: rs113488022
rs113488022
T 0.800 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Therefore the BRAF V600E mutation is a highly interesting oncological target in brain tumors. 27350555

2016

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Among brain tumors, the BRAF (V600E) mutation is frequently associated with pleomorphic xanthoastrocytomas (PXAs) and gangliogliomas (GGs). 26264609

2015

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE An institutional cohort of 105 brain tumors (51 dysembryoplastic neuroepithelial tumors (DNTs), 14 subependymal giant cell astrocytomas (SEGAs), 12 glioblastoma with neuronal marker expression (GBM-N), and 28 pleomorphic xanthoastrocytomas (PXAs)) from 100 patients were investigated for the presence of BRAF(V600E) by direct sequencing. 25346165

2015

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma, ganglioglioma, and pilocytic astrocytoma, and less frequently in epithelioid and giant cell glioblastoma. 25885250

2015

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE The patient's resected brain tumor is BRAF V600E mutated, NRAS wild type (WT), and TERT C250T mutated. 26597176

2015

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE An activating mutation of BRAF (BRAF-V600E) has been reported in a subset of malignant brain tumors. 24721513

2014

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Future clinical trials should address whether BRAF V600E mutant brain tumour patients will benefit from BRAF V600E-directed targeted therapies. 24353007

2014

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE PKM2-regulated MLC2 phosphorylation, which is greatly enhanced by EGF stimulation or EGFRvIII, K-Ras G12V and B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumour development. 25412762

2014

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE BRAF V600E-mutations have been described in a modest 6% to 7% of primary central nervous system (CNS) tumors, but with increased prevalence in the pediatric population and in certain brain tumor subtypes. 24725538

2014

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors. 25484091

2014

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. 24823863

2014

dbSNP: rs113488022
rs113488022
T 0.800 GeneticVariation CLINVAR Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. 22586120

2012

dbSNP: rs113488022
rs113488022
T 0.800 GeneticVariation CLINVAR Targeted therapy for BRAFV600E malignant astrocytoma. 22038996

2011

dbSNP: rs113488022
rs113488022
0.800 GeneticVariation BEFREE Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies. 21274720

2011