rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Based on these results, we propose that all female carriers of 40-50 years of age and female ATM c.7271T>G mutation carriers from 25 years of age onwards be offered intensified surveillance programs for breast cancer.
|
26662178 |
2016 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
For European women, strong evidence of association with breast cancer risk was observed for PALB2 c.1592delT OR 3.44 (95% CI 1.39 to 8.52, p=7.1×10<sup>-5</sup>), PALB2 c.3113G>A OR 4.21 (95% CI 1.84 to 9.60, p=6.9×10<sup>-8</sup>) and ATM c.7271T>G OR 11.0 (95% CI 1.42 to 85.7, p=0.0012).
|
27595995 |
2016 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
These findings suggest that although the more common c.1066-6T>G variant is not associated with breast cancer, the rare ATM c.7271T>G variant is associated with a substantially elevated risk.
|
16958054 |
2006 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We validated the expression differences by RT-PCR in additional heterozygous V2424G LCLs from another breast cancer family.
|
17001622 |
2006 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We conclude that the ATM IVS10-6T-->G mutation does not confer a significantly elevated breast cancer risk and that ATM 7271T-->G is a rare event in familial breast cancer.
|
14871810 |
2004 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Recent reports suggest that two ATM gene mutations, 7271T>G and IVS10-6T>G, are associated with a high risk of breast cancer among multiple-case families.
|
14562025 |
2003 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Nevertheless, two recurrent ATM mutations, T7271G and IVS10-6T-->G, reportedly increase the risk of breast cancer.
|
11830610 |
2002 |
rs28904921
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We report, in two A-T families, an ATM mutation (7271T-->G) that may be associated with an increased risk of breast cancer in both homozygotes and heterozygotes (relative risk 12.7; P=.
|
9463314 |
1998 |
rs28904921
|
|
G |
0.780 |
CausalMutation |
CLINVAR |
|
|
|
rs587779852
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In the combined analysis, E1978X was significantly associated with breast cancer (Mantel-Haenszel OR: 5.6, 95% CI: 1.3-21.4, P = 0.01).
|
18807267 |
2009 |
rs587779852
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
rs1131691164
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1137887
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1185204988
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs138941496
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs139770721
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1555069815
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1555070980
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1555093684
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1555119041
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1565503137
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs17174393
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs377349459
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs397514577
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs532480170
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|