rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up.
|
21179003 |
2011 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The rs9939609 A allele, which was associated with higher BMI in the sample, was inversely associated with overall (odds ratio (OR) versus all controls = 0.93; 95% confidence interval (CI): 0.85-1.02 p = 0.12 per allele) and low-grade (OR = 0.90; 0.81-0.99 p = 0.03 per allele) prostate cancer risk, but positively associated with high-grade cancer among cases (OR high- versus low-grade cancer = 1.16; 0.99-1.37 p = 0.07 per allele).
|
20976066 |
2010 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609).
|
19726594 |
2009 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Variants (such as rs9939609) in the fat mass- and obesity-associated (FTO) gene have been associated with obesity, type 2 diabetes, some cancers, and alcohol consumption.
|
23771786 |
2013 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (<i>N</i> = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (<i>FTO</i> gene rs9939609 polymorphism) factors.
|
29675043 |
2018 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Our meta-analysis indicated that there was no association between FTO rs9939609 polymorphism and the increased risk of c</span>ancer, although this polymorphism was marginally associated with pancreatic cancer.
|
22396042 |
2012 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Besides, in the subgroup analysis of ethnicity, our results indicated that rs9939609 polymorphism was significantly associated with cancer risk in Asians.
|
26931363 |
2017 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
However, <i>FTO</i> rs9939609 variant was associated with some types of cancer in the subgroup analysis.
|
28881622 |
2017 |
rs9939609
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The rs9939609 polymorphism in the FTO gene has recently been implicated as a risk factor for some types of cancer, such as breast, pancreatic, and prostate cancers.
|
29260910 |
2018 |
rs1800625
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Therefore, we performed a systematic review to identify statistical evidence of the association between the 3 polymorphisms rs2070600 G/S (82G>S), rs1800624 T/A ( -374 T>A) and rs1800625C/T (-429 C>T) and the risk of cancer.
|
26011358 |
2015 |
rs1800625
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We failed to get an effective conclusion about the association between the rs1800624 and rs1800625 polymorphisms and cancer risk in overall comparison.
|
26011358 |
2015 |
rs1800625
|
|
|
0.720 |
GeneticVariation |
BEFREE |
CONCLUSIONS In conclusion, the RAGE rs1800625 polymorphism was associated with increased overall cancer risk in Asians in recessive genetic model.
|
31534114 |
2019 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk.
|
31759353 |
2019 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk.
|
17909070 |
2007 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, this study explores the single and combined effects of cancer risk, age of onset and cancer type of three single nucleotide polymorphisms (SNPs)-TP53 Pro72Arg, MDM2 SNP285 and SNP309-already described as modifiers on TP53 mutation carriers but not properly investigated in LFS Suggestive patients.
|
26956143 |
2016 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg).
|
24935583 |
2014 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prognostic significance of the Arg72Pro polymorphism of the p53 tumour suppressor gene in cancer is controversial.
|
17400332 |
2007 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The germ-line polymorphisms TP53 Arg72Pro and MDM2 SNP309 T>G are risk factors for tumor development and affect response to chemotherapy and survival in several cancers, but their prognostic and predictive value in patients with high-grade osteosarcomas is not yet defined.
|
19451596 |
2009 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Mouse models for the p53 R72P polymorphism have recently been developed but a role for this SNP in modifying cancer risk in response to viral and chemical carcinogens has yet to be established experimentally.
|
23475592 |
2014 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To explore the impact of the p53 PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer.
|
17374954 |
2006 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
p53 gene variants i.e.16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies.
|
23621193 |
2013 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have also found that the ectopic expression of p53-R248W/P72R in MG63 cells promoted cancer stem-like features, as high proliferation rate, sphere formation, clonogenic growth, high migration and invasive ability; furthermore, it strongly increased the levels of stemness proteins.
|
24373920 |
2014 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have indicated that the <i>TP53</i> gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer.
|
28275206 |
2017 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg).
|
24935583 |
2014 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the p53 R72P polymorphism.
|
28594296 |
2017 |