Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs701848
rs701848
0.030 GeneticVariation BEFREE Moreover, the SNP rs701848 CC, TC genotype showed significantly increased the overall cancer risk both in dominant model [CC/TC vs. TT: OR(95% CI) = 1.25(1.15, 1.36)] and recessive model [CC vs. 29259266

2017

dbSNP: rs701848
rs701848
0.030 GeneticVariation BEFREE This meta-analysis indicates that the <i>PTEN</i> rs701848 (CC) and rs2735343 (GG) polymorphisms are associated with increased cancer risk in Asian subjects. 29221206

2017

dbSNP: rs701848
rs701848
0.030 GeneticVariation BEFREE Epidemiologic studies suggested that mutations of the PI3K/PTEN/AKT pathway genes are associated with cancer risk, yet no data are available for PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 polymorphism and breast cancer(BC) risk. 28423632

2017

dbSNP: rs3830675
rs3830675
0.030 GeneticVariation BEFREE Impact of PTEN IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis. 26417029

2016

dbSNP: rs3830675
rs3830675
0.030 GeneticVariation BEFREE Association of the PTEN IVS4 (rs3830675) gene polymorphism with reduced risk of cancer: evidence from a meta-analysis. 25735379

2015

dbSNP: rs3830675
rs3830675
0.030 GeneticVariation BEFREE The recessive effect model and dominant effect model also demonstrated significant association between PTEN IVS4 (rs3830675) polymorphism and increased cancer risk especially for digestive tract cancer. 24901890

2014

dbSNP: rs121909235
rs121909235
0.010 GeneticVariation BEFREE To our knowledge, this is the first report of PDAC associated with a germline PTEN mutation, particularly a rare variant (p.Arg234Gln</span>) with cancer risks. 28755079

2018

dbSNP: rs2735343
rs2735343
0.010 GeneticVariation BEFREE This meta-analysis indicates that the <i>PTEN</i> rs701848 (CC) and rs2735343 (GG) polymorphisms are associated with increased cancer risk in Asian subjects. 29221206

2017

dbSNP: rs121909224
rs121909224
0.010 GeneticVariation BEFREE We used whole exome sequencing to examine the mutation profiles of the LMD tumor DNA in CSF before therapeutic response and after disease relapse, and discovered a canonical cancer mutation PTEN (R130*) at both time points. 26961773

2016

dbSNP: rs779530981
rs779530981
0.010 GeneticVariation BEFREE This combination treatment ultimately leads to the expansion of cancer progenitors with a PTEN E91D mutation, suggesting that the analysis of PTEN mutations could predict therapeutic response to the dual therapy. 21138868

2010

dbSNP: rs1029342144
rs1029342144
0.010 GeneticVariation BEFREE Statistically significant associations were noted between SNPs in beta-catenin and APOE and a positive family history of cancer (beta-catenin: p=0.034, APOE: p=0.033); tumor location and a DCC SNP (p=0.038) and the P53 R72P mutation and survival (p=0.0336). 15523694

2005