|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The MTHFR A1298C polymorphism was associated with risk of colon cancer.
|
24533714 |
2014 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, risk was significantly increased for MTHFR A1298C polymorphisms and colon cancer risk in hospital-based studies (C vs A: OR=1.52, 95%CI=1.26-1.83, p=0.000; CC+AC vs AA: OR=1.93, 95%CI=1.47-2.49, p=0.000) but reduced in population-based studies (CC vs AA: OR=0.83, 95%CI=0.70-0.99, p=0.042).
|
25339013 |
2014 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A haplotype of A66G and A1298C polymorphisms, A/A, proved to be protective (OR=0.775; 95% CI=0.603-0.996; p=0.04), whereas haplotype A/G was a risk factor for colon cancer (OR=1.270; 95% CI=1.007-1.602; p=0.04).
|
21438757 |
2011 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Interactions were observed between the MTHFR A1298C polymorphism and bowel habits, family history of cancer, alcohol consumption, and beef consumption on colon cancer risk (P-value for interaction = 0.0005, 0.007, 0.067, 0.003, respectively).
|
20551579 |
2010 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Individuals who had C677T T/T and A1298C A/A genotypes were at an increased risk of developing colon cancer (adjusted OR=2.64, 95%CI: 1.20-5.81) compared with those with C677T C allele and A1298C A/A genotypes among males.
|
18712959 |
2009 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of environmental factors (dietary folate, methionine and drinking status) and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene, as well as the combination of these factors, with the risk of colon cancer and rectal cancer.
|
15829374 |
2005 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
While the A1298C polymorphism showed no measurable association with the overall risk of colorectal cancer, the 1298CC genotype was associated with a statistically significant increase in the risk when alcohol consumption was high, and was also associated with an approximately 2-fold increase in the risk of each of proximal and distal colon cancer.
|
15546509 |
2004 |
|
rs397507444
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In summary, this study supports recent findings that the MTHFR A1298C polymorphism may be a predictor of colon cancer risk and have functional relevance.
|
14973104 |
2004 |