Gene: ERBB2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs397516976
rs397516976
ERBB2 ; MIR4728
ACGTGATGGCCTC 0.700 GeneticVariation CLINVAR Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. 22761469

2012
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. 22325357

2012
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. 22761469

2012
dbSNP: rs397516982
rs397516982
ERBB2 ; MIR4728
GGGCTCCCCA 0.700 GeneticVariation CLINVAR Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. 22761469

2012
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma. 18334834

2008
dbSNP: rs397516979
rs397516979
ERBB2 ; MIR4728
GTGT 0.700 GeneticVariation CLINVAR EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification. 16863509

2006
dbSNP: rs397516980
rs397516980
ERBB2 ; MIR4728
TTAT 0.700 GeneticVariation CLINVAR Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain. 16825508

2006
dbSNP: rs397516980
rs397516980
ERBB2 ; MIR4728
TTAT 0.700 GeneticVariation CLINVAR HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. 16775247

2006
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. 16638863

2006
dbSNP: rs397516979
rs397516979
ERBB2 ; MIR4728
GTGT 0.700 GeneticVariation CLINVAR Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. 15753357

2005
dbSNP: rs397516980
rs397516980
ERBB2 ; MIR4728
TTAT 0.700 GeneticVariation CLINVAR Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. 15753357

2005
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. 15753357

2005
dbSNP: rs397516982
rs397516982
ERBB2 ; MIR4728
GGGCTCCCCA 0.700 GeneticVariation CLINVAR Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. 15753357

2005
dbSNP: rs397516976
rs397516976
ERBB2 ; MIR4728
ACGTGATGGCCTC 0.700 GeneticVariation CLINVAR Lung cancer: intragenic ERBB2 kinase mutations in tumours. 15457249

2004
dbSNP: rs397516982
rs397516982
ERBB2 ; MIR4728
GGGCTCCCCA 0.700 GeneticVariation CLINVAR Lung cancer: intragenic ERBB2 kinase mutations in tumours. 15457249

2004
dbSNP: rs1555618025
rs1555618025
ERBB2 ; MIR4728
ACGTGATGGCTTC 0.700 GeneticVariation CLINVAR

dbSNP: rs397516975
rs397516975
ERBB2 ; MIR4728
AGCATACGTGATG 0.700 GeneticVariation CLINVAR

dbSNP: rs397516977
rs397516977
ERBB2 ; MIR4728
ATACGTGATGGCT 0.700 GeneticVariation CLINVAR

dbSNP: rs397516978
rs397516978
ERBB2 ; MIR4728
G 0.700 GeneticVariation CLINVAR

dbSNP: rs397516979
rs397516979
ERBB2 ; MIR4728
GTTT 0.700 GeneticVariation CLINVAR

dbSNP: rs372043866
rs372043866
ERBB2
0.020 GeneticVariation BEFREE Here, we report a case of an advanced chemotherapy-resistant NSCLC, harboring a novel HER3(V855A) somatic mutation homologous to the EGFR(L858R)activating mutation. 26689995

2016
dbSNP: rs372043866
rs372043866
ERBB2
0.020 GeneticVariation BEFREE It is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) carrying EGFR exon 19 deletions or exon 21 (L858R) mutations. 24844234

2014
dbSNP: rs758222990
rs758222990
ERBB2 ; MIR4728
0.010 GeneticVariation BEFREE This is the first case report describing a NSCLC patient harboring a rare <i>HER2</i> R896G mutation who responds to afatinib. 31849493

2019