|
rs3918226
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu298Asp is a single nucleotide polymorphism (SNP) in the eNOS gene related to the risk of cardiovascular disease.
|
31442681 |
2020 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease.
|
29973202 |
2018 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The risk also holds for the G894T and T-786C eNOS gene polymorphisms when excluding patients with dyslipidemia and cardiovascular diseases (p = 1.7·10<sup>-4</sup> and p = 3.2·10<sup>-5</sup> , respectively).
|
30101547 |
2018 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases.
|
23922896 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the eNOS gene, where thymine (T) replaces guanine (G) at position 894 predicting substitution of glutamate for aspartate at codon 298 (Glu298Asp), has been associated with increased CVD risk due to effects on nitric oxide synthesis and subsequently vascular reactivity.
|
22689471 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results both provide insight into the higher risk of CVD attributed to E298D and identify variants that affect MEF in a healthy population.
|
20870316 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that eNOS gene polymorphisms (T-786C and Glu298Asp) are not associated with an increased risk for cardiovascular diseases in MeHg-exposed subjects.
|
21899406 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases.
|
21623032 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we found that eNOS G894T polymorphism was associated with the presence and severity of renal disease and with CVD in CRD patients (P=0.028, P=0.018, P=0.016 respectively).
|
19376104 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The -786T>C, but not the Glu298>Asp variant of NOS3, may correlate with BP but do not appear to be associated with incident cardiovascular events in patients with established cardiovascular disease.
|
19407804 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In analyses of CVD development using Cox-regression the rs1799983 GG-genotype was a significant protective factor in normoalbuminuric patients, HR=0.32 (0.12-0.82), P=0.018, but not in patients with macroalbuminuria (covariates were; age at follow-up, baseline Hb(A1c), baseline systolic blood pressure, baseline cholesterol, sex and ever smoking).
|
19246226 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the Glu298Asp (894G --> T) polymorphism in exon 7 of the eNOS gene was significantly different between control subjects (TT:GT:-GG = 7.7%:29.5%:62.8%) and patients with CVD (TT:GT:GG = 5.0%:74.2%:20.8%).
|
18551994 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One SNP (Glu298Asp) was related to FMD (nominal P=0.0018), but not to EDV (nominal P=0.76) after adjustment for sex, systolic blood pressure, diastolic blood pressure, pulse rate, antihypertensive treatment, total cholesterol, high-density cholesterol, lipid-lowering medication, fasting glucose, antidiabetic medication, body mass index, current smoking and prior diagnosis of cardiovascular disease.
|
18463668 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An interaction between the E298D and T-786C polymorphisms in NOS3, cigarette smoking, and risk of incident coronary heart disease and ischemic stroke events appears to exist, suggesting a potential complex interplay between genetic and environmental factors and cardiovascular disease risk.
|
17108813 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This review examines the association of a subset of endothelial nitric oxide synthase gene (NOS3) polymorphisms (Glu298Asp, intron 4, and -786T>C) with cardiovascular disease.
|
17018701 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu(298)-->Asp (E298D; 894G-->T) polymorphism of eNOS (endothelial nitric oxide synthase) has been related with cardiovascular disease.
|
16060860 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results imply that G894T polymorphism of the endothelial nitric oxide synthase gene is associated with elevated levels of inflammatory and oxidative stress markers, which may partially explain the increased prevalence of G894T polymorphism among patients with cardiovascular disease.
|
15459608 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An insertion/deletion (I/D) polymorphism in the gene encoding the ACE and a single nucleotide exchange polymorphism (G894T) in the gene NOS3 encoding endothelial nitric oxide synthase have been associated with cardiovascular disorders.
|
12837457 |
2003 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease.
|
12065317 |
2002 |
|
rs1341139296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genetic study on long-living individuals-who are characterized by delays in ageing and in the onset of cardiovascular disease-previously revealed I229V (rs2070325) in bactericidal/permeability-increasing fold-containing-family-B-member-4 (BPIFB4) as a longevity-associated variant (LAV); the LAV protein enhanced endothelial NO production and vasorelaxation through a protein kinase R-like endoplasmic reticulum kinase/14-3-3/heat shock protein 90 signal.
|
28419216 |
2017 |
|
rs743507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Biomarkers of CVD risk, plasma fatty acid composition, and NOS3 single nucleotide polymorphism (SNP) genotype (rs11771443, rs1800783, rs1800779, rs1799983, rs3918227, and rs743507) were determined in 450 individuals with the MetS from the LIPGENE dietary intervention cohort.
|
20409549 |
2010 |
|
rs375752214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.
|
15494775 |
2004 |