Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The Glu298Asp is a single nucleotide polymorphism (SNP) in the eNOS gene related to the risk of cardiovascular disease. 31442681

2020

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease. 29973202

2018

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The risk also holds for the G894T and T-786C eNOS gene polymorphisms when excluding patients with dyslipidemia and cardiovascular diseases (p = 1.7·10<sup>-4</sup> and p = 3.2·10<sup>-5</sup> , respectively). 30101547

2018

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. 23922896

2013

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE A single nucleotide polymorphism in the eNOS gene, where thymine (T) replaces guanine (G) at position 894 predicting substitution of glutamate for aspartate at codon 298 (Glu298Asp), has been associated with increased CVD risk due to effects on nitric oxide synthesis and subsequently vascular reactivity. 22689471

2012

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Our results both provide insight into the higher risk of CVD attributed to E298D and identify variants that affect MEF in a healthy population. 20870316

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Our findings suggest that eNOS gene polymorphisms (T-786C and Glu298Asp) are not associated with an increased risk for cardiovascular diseases in MeHg-exposed subjects. 21899406

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative candidate gene for cardiovascular diseases. 21623032

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE However, we found that eNOS G894T polymorphism was associated with the presence and severity of renal disease and with CVD in CRD patients (P=0.028, P=0.018, P=0.016 respectively). 19376104

2009

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The -786T>C, but not the Glu298>Asp variant of NOS3, may correlate with BP but do not appear to be associated with incident cardiovascular events in patients with established cardiovascular disease. 19407804

2009

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In analyses of CVD development using Cox-regression the rs1799983 GG-genotype was a significant protective factor in normoalbuminuric patients, HR=0.32 (0.12-0.82), P=0.018, but not in patients with macroalbuminuria (covariates were; age at follow-up, baseline Hb(A1c), baseline systolic blood pressure, baseline cholesterol, sex and ever smoking). 19246226

2009

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The frequency of the Glu298Asp (894G --> T) polymorphism in exon 7 of the eNOS gene was significantly different between control subjects (TT:GT:-GG = 7.7%:29.5%:62.8%) and patients with CVD (TT:GT:GG = 5.0%:74.2%:20.8%). 18551994

2008

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE One SNP (Glu298Asp) was related to FMD (nominal P=0.0018), but not to EDV (nominal P=0.76) after adjustment for sex, systolic blood pressure, diastolic blood pressure, pulse rate, antihypertensive treatment, total cholesterol, high-density cholesterol, lipid-lowering medication, fasting glucose, antidiabetic medication, body mass index, current smoking and prior diagnosis of cardiovascular disease. 18463668

2008

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE An interaction between the E298D and T-786C polymorphisms in NOS3, cigarette smoking, and risk of incident coronary heart disease and ischemic stroke events appears to exist, suggesting a potential complex interplay between genetic and environmental factors and cardiovascular disease risk. 17108813

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE This review examines the association of a subset of endothelial nitric oxide synthase gene (NOS3) polymorphisms (Glu298Asp, intron 4, and -786T>C) with cardiovascular disease. 17018701

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The Glu(298)-->Asp (E298D; 894G-->T) polymorphism of eNOS (endothelial nitric oxide synthase) has been related with cardiovascular disease. 16060860

2005

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Our results imply that G894T polymorphism of the endothelial nitric oxide synthase gene is associated with elevated levels of inflammatory and oxidative stress markers, which may partially explain the increased prevalence of G894T polymorphism among patients with cardiovascular disease. 15459608

2004

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE An insertion/deletion (I/D) polymorphism in the gene encoding the ACE and a single nucleotide exchange polymorphism (G894T) in the gene NOS3 encoding endothelial nitric oxide synthase have been associated with cardiovascular disorders. 12837457

2003

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. 12065317

2002