Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE A subgroup analysis based on ethnicity showed that the allelic (p < 0.00001, OR = 0.65) and dominant models (p < 0.00001, OR = 0.61) of rs11209026 polymorphism were significantly associated with UC risk in Caucasians, but not in Asians (p > 0.05). 31728561

2020

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Finally, rs8074524 and rs10758669 in Crohn's disease and rs11209026 in ulcerative colitis were associated with disease-related operation. 27852544

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans. 26887945

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases. 27043356

2016

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE Our meta-analysis supports that two polymorphisms (rs11209026 and rs7517847) in the IL-23 gene may be considered to be protective factors against developing UC among Caucasian populations; while the rs11209032 polymorphisms may increase the risk of UC among Caucasian populations; furthermore, the rs1088967 polymorphisms in the IL-23 gene may be considered to be protective factors against developing UC among Asian populations. 25497273

2015

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC. 24971461

2014

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASDB Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633

2011

dbSNP: rs11209026
rs11209026
G 0.900 GeneticVariation GWASCAT Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633

2011

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880). 20082483

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females. 19294505

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880). 20082483

2010

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation GWASDB Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. 19915572

2009

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation GWASCAT Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. 19915572

2009

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation GWASDB Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. 19122664

2009

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC. 19276991

2009

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation GWASCAT Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. 19122664

2009

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC. 17786191

2007

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE We also provide further evidence for association of rs11209026 with UC and a report of an additive effect between IL23R and CARD15 genotypes in CD. 17894849

2007

dbSNP: rs11209026
rs11209026
0.900 GeneticVariation BEFREE The p.Arg381Gln IL23R variant confers a protective effect against both CD and UC, but does not determine disease phenotype. 17877509

2007

dbSNP: rs1801274
rs1801274
0.850 GeneticVariation BEFREE The minor homozygote (CC) of FCGR2A (rs1801274) may contribute to decrease the susceptibility to UC and the TC haplotype formed by FCGR2A (rs1801274 and rs511278) may increase the risk of UC in the Chinese population. 30260678

2018

dbSNP: rs1801274
rs1801274
0.850 GeneticVariation BEFREE This association seemed to be modified by the UC susceptibility locus, rs1801274, a coding variant in the FcγRIIA gene (Pinteraction = 7.00E-05). 28604414

2017

dbSNP: rs1801274
rs1801274
0.850 GeneticVariation GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908

2017

dbSNP: rs1801274
rs1801274
0.850 GeneticVariation BEFREE This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC. 27270653

2016

dbSNP: rs1801274
rs1801274
0.850 GeneticVariation BEFREE We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10). 26398853

2016

dbSNP: rs1801274
rs1801274
0.850 GeneticVariation BEFREE Six CSE-induced genes in DLD-1 cells were located in UC-susceptibility loci, including HSPA6 (rs1801274). 26826017

2016