rs28930073
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The MLH1 D132H risk variant has significantly lower allele frequency in American compared with Israeli cancer patients and, alone, is unlikely to explain significant amounts of American sporadic colorectal cancer or uterine cancer susceptibility.
|
15991064 |
2005 |
rs28930073
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Association studies identified a new MLH1 variant (415G-->C, resulting in the amino acid substitution D132H) in approximately 1.3% of Israeli individuals with CRC self-described as Jewish, Christian and Muslim.
|
15184898 |
2004 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Here we use the presence of a colorectal cancer (CRC) risk variant (rs1800734) within the MLH1 promoter to investigate the poorly understood mechanisms of MLH1 promoter methylation and loss of expression.
|
31530880 |
2019 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients.
|
23240038 |
2012 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
When candidate SNPs were examined, our data did not support most of the previously reported associations with CRC susceptibility, an exception being an effect of the MLH1 promoter SNP -93G>A (rs1800734).
|
22294770 |
2012 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To explore these distinct patterns, MLH1 CpG island and shore methylation was assessed in CRC cell lines stratified by rs1800734 genotype.
|
28304185 |
2017 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We evaluated the significance of rs1800734 on CRC risk by genotyping 10 409 CRC cases and 6965 controls.
|
21565826 |
2011 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) in the CpG island of <i>MLH1</i> (<i>MLH1</i>-93G>A or rs1800734) is associated with CpG island hypermethylation and decreased <i>MLH1</i> expression in CRC tumours.
|
28293327 |
2017 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Additionally, there was no persuasive evidence showing that SNPs of rs1800734 and rs1799977 were related to CRC susceptibility.
|
25986311 |
2015 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The observed association of rs1800734 with MSI-H CRC occurs through its effect on the MLH1 promoter methylation, MLH1 IHC deficiency, or both.
|
20967208 |
2010 |
rs1800734
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The MLH1 -93G>A (rs1800734) polymorphism was detected by PCR-RFLP in 49 cases of colorectal cancer.
|
25115745 |
2014 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Two SNPs of hMLH1 (hMLH1 -93G>A and IVS3-1403A>T) were significantly associated with OS of CRC in dominant model and recessive model, respectively.
|
24793746 |
2014 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that the MLH1 -93G>A polymorphism defines a low penetrance risk allele for CRC.
|
18712731 |
2008 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The -93G > A (rs1800734) polymorphism within the core promoter region of the MutL homolog 1 (MLH1) gene has recently been proposed as a low penetrance variant for colorectal cancer (CRC).
|
21565826 |
2011 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The MLH1 -93 G>A promoter polymorphism has been reported to be associated with an increased risk of microsatellite unstable colorectal cancer.
|
18615680 |
2008 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results suggest an influence of MLH1 promoter polymorphism -93G>A in modulating susceptibility risk in Malaysian CRC patients, especially those with sporadic disease.
|
23621208 |
2013 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The MLH1 -93G>A (rs1800734) polymorphism was detected by PCR-RFLP in 49 cases of colorectal cancer.
|
25115745 |
2014 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results suggest that the MLH1 -93G>A polymorphism may contribute to individual susceptibility to CRC and act as a risk factor for MSI-CRC.
|
23226285 |
2012 |
rs876658657
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Among case patients from Ontario, an association between the MLH1 -93G>A polymorphism and a strong family history of colorectal cancer (for Amsterdam criteria I and II, P = .004 and P = .02, respectively) was observed.
|
17374836 |
2007 |
rs1799977
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In relation to the more frequent 655A-->G polymorphism, association analyses revealed that G carriers (AG or GG genotype) displayed a higher risk of CRC compared with AA homozygous [odds ratio (OR) AG=2.55, 95% confidence interval (CI)=1.48-4.39; P=0.01 and OR GG=2.48, 95% CI=1.20-5.11; P=0.01, respectively].
|
19665066 |
2009 |
rs1799977
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The MLH1 I219V polymorphism was associated with colorectal cancer susceptibility (P=0.01).
|
24595079 |
2013 |
rs1799977
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Additionally, there was no persuasive evidence showing that SNPs of rs1800734 and rs1799977 were related to CRC susceptibility.
|
25986311 |
2015 |
rs1799977
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The G allele of rs1799977 polymorphism was proved to connect with susceptibility of colorectal cancer (allele model: OR = 1.21, P = 0.023; dominate model: OR = 1.32, P <0.0001) and prostate cancer (dominate model: OR = 1.36, P <0.0001).
|
29190978 |
2017 |
rs1799977
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms in 3 mismatch repair genes (MSH3 R940Q, MSH3 T1036A, MSH6 G39E and MLH1 I219V) were genotyped in 237 colorectal cancer cases and a subcohort of 2,189 participants.
|
17205513 |
2007 |
rs56250509
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status.
|
18595133 |
2008 |