rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
LOH analysis revealed preferential retention of three SNPs, rs12657484, rs3802842, and rs4444235, in tumor tissues. rs4444235 has been recently reported to be a cis-acting regulator of BMP4 gene; in this study, the C allele was preferentially retained in tumor tissues (p = 0.0023). rs4631962 and rs10795668 contribute to CRC risk in the Taiwanese and East Asian populations, and the newly identified rs1338565 was specifically associated with CRC, supporting the ethnic diversity of CRC-susceptibility SNPs.
|
24968322 |
2014 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped four variants previously associated with CRC: rs10795668, rs16892766, rs3802842 and rs4939827.
|
24066093 |
2013 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed an association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q = 0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q = 0.041), both in tumor samples.
|
22363440 |
2012 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Furthermore, we found that rs10795668 was associated with increased risk only in rectal cancer but not colon cancer, and rs3802842 was also significantly associated with advanced stages of CRC.
|
20530476 |
2010 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, CRC susceptibility variants rs9929218 and rs10795668 may exert some influence in modulating patient's survival and they deserve to be further tested in additional CRC cohorts in order to confirm their potential as prognosis or predictive biomarkers.
|
23712746 |
2013 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data suggested that rs10795668, a CRC susceptibility variant identified by GWA studies, might be used as a biomarker to identify CRC patients with high risk of recurrence after chemotherapy.
|
21402474 |
2011 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results from our case-control study and the followed meta-analysis confirmed the significant association of rs10795668 with CRC risk.
|
23717594 |
2013 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In contrast, in African Americans, the opposite allele of rs10795668 at 10p14 was associated with colorectal cancer (odds ratio, 1.35; P = .04), and altogether the odds ratios were in the opposite direction for 9 of the 22 SNPs tested.
|
20659471 |
2010 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs4939827, rs4779584, and rs10795668 may contribute to the risk of CRC in the Korean population as well as in European populations.
|
23875689 |
2015 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
rs10795668
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We studied the role of the 8q24.21 (rs6983267), 18q21.1 (rs12953717), 15q13.3 (rs4779584), 11q23.1 (rs3802842), 8q23.3 (rs16892766), and 10p14 (rs10795668) risk variants in a series of 995 Dutch CRC cases and 1340 controls.
|
19843678 |
2009 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In advanced CRCs, KRAS mutations occurred in 48% of cases (64% codons 12/13, 36% other codons) and BRAF mutations in 10% (66% V600E, 33% exon 11).
|
19474002 |
2009 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Mutation analysis of 66 arbitrary selected colorectal carcinomas revealed that CD274-positive tumors usually (88%) carried the BRAF V600E mutation.
|
27813511 |
2017 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, this method was proven to distinguish the BRAF V600E mutant from the wild type based on intrinsic differences by using a total of 312 CRC tissue samples paraffin-embedded, deparaffinized, and stained.
|
31208050 |
2019 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
BRAF V600E and SRC mutations are important molecular markers which can predict prognosis and conversion surgery in Stage IV CRC.
|
30792536 |
2019 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Detection of the BRAF V600E </span>mutation in colorectal cancer by immunohistochemistry is a viable alternative to molecular methods.
|
23650027 |
2013 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Here, we measured the prevalence and epidemiologic correlates of the BRAF V600E somatic mutation in cases collected as a part of a population-based case-control study of CRC in northern Israel.
|
20200438 |
2010 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that a single endogenous BRAF(V600E) allele is sufficient to repress BIM and prevent death arising from growth factor withdrawal, and CRC cells with BRAF(V600E) mutations are addicted to the ERK1/2 pathway for repression of BIM and growth factor-independent survival.
|
18806830 |
2008 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
High-frequency microsatellite instability and BRAF mutation (V600E) in unselected Serbian patients with colorectal cancer.
|
22210186 |
2012 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To summarize the usefulness of several recently discovered immunohistochemical markers in the study of gastrointestinal and liver tumors; to suggest the most current and effective immunohistochemical panels addressing common diagnostic challenges for these tumors; to share practical experience and useful tips for human epidermal growth factor receptor 2 testing in gastric and gastroesophageal junction adenocarcinoma and v-raf murine sarcoma viral oncogene homolog B V600E immunohistochemistry in colorectal carcinoma.
|
25549141 |
2015 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A correlation between MLH1 promoter methylation, specifically the 'C' region, and BRAF V600E status has been reported in CRC studies.
|
23880961 |
2014 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
When subclassified by combined BRAF V600E mutation and MMR status, loss of ARID1A expression was found most commonly in CRCs with the BRAF V600E mutated, MMR- deficient phenotype (58 of 232 cases, 25%, P < .01).
|
24925223 |
2014 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Activating V600E mutation in BRAF gene has been linked with widespread methylation of CpG islands in sporadic colorectal cancers.
|
21455633 |
2011 |
rs113488022
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association between methylation in mismatch repair genes, V600E BRAF mutation and microsatellite instability in colorectal cancer patients.
|
21681432 |
2012 |