Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE In this study, a panel of 5 SNPs, namely ABCC2 (-24C > T/rs717620 and c.4544 G > A/rs8187710), ABCG2 (c.421 C > A/rs2231142), ABCB1 (c.3435 C > T/rs1045642) and SLC31A1 (c.-36 + 2451 T > G/rs10981694), was evaluated to assess their association with grade 2-3 OXPN in metastatic CRC patients. 30713338

2019

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE In summary, this meta-analysis provided evidence that MDR1 C3435T polymorphism is associated with a decreased risk of CRC in Asian population. 29390571

2017

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE In a three-way analysis, both ABCB1/rs1045642 and ABCG2/rs2231137 in combination with IL10/rs3024505 interacted with fiber intake in relation to risk of CRC (P(int) = 0.0007 and 0.009). 26109419

2015

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE We observed that the ABCB1 C3435T and G2677T/A variants as well as the 3435T-1236T-2677T haplotype significantly increased the risk of CRC. 23746184

2013

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Compared with the ABCB1 gene SNPs rs1045642, rs2032582 or rs3789243 alone, combined haplotypes of several SNPs might be a better marker to determine the genetic influence on the susceptibility to colorectal cancer among Caucasians. 23279665

2013

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T). 23193993

2013

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). 23977225

2013

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Collectively, the results of the present study suggest that there were no significant associations of ABCB1/MDR1 C3435T</span> polymorphism with colorectal cancer observed for all comparison models. 23504525

2013

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Carriers of the rs1202168_T and rs868755_T alleles had an increased risk for CRC (P(trend) = 0.016 and 0.029, respectively), while individuals bearing the rs1045642_C allele showed a decreased risk of CRC (P(trend) = 0.022). 22396794

2012

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer. 20127181

2011

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC). 20533057

2010

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Carriers of the variant allele of MDR1 C3435T exon 26 had a lower risk of CRC than homozygous C-allele carriers (IRR = 0.71 (CI:0.50-1.00)). 19930591

2009

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients. 17674045

2008

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry. 12894567

2003

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T). 23193993

2013

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE We observed that the ABCB1 C3435T and G2677T/A variants as well as the 3435T-1236T-2677T haplotype significantly increased the risk of CRC. 23746184

2013

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE Compared with the ABCB1 gene SNPs rs1045642, rs2032582 or rs3789243 alone, combined haplotypes of several SNPs might be a better marker to determine the genetic influence on the susceptibility to colorectal cancer among Caucasians. 23279665

2013

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC). 20533057

2010

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer. 19415305

2009

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE The aim of the present study is to genotype the MDR1 2677G>T (rs2032582) and 3435C>T (rs1045642) polymorphism in patients with colorectal cancer and controls and to identify a possible association between individual genetic variation and susceptibility to colorectal cancer. 17674045

2008

dbSNP: rs2032582
rs2032582
0.070 GeneticVariation BEFREE In particular, carriers of the T/T genotype in exon 12 (1236 C-->T) SNP and the T/T genotype in exon 21 (2677G-->T) SNP were most significantly associated with a higher risk for developing MSI-H CRC compared to controls (P=0.01, OR=3.182 and P=0.005, OR=3.594, respectively). 18474294

2008

dbSNP: rs1128503
rs1128503
0.040 GeneticVariation BEFREE Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T). 23193993

2013

dbSNP: rs1128503
rs1128503
0.040 GeneticVariation BEFREE To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC). 20533057

2010

dbSNP: rs1128503
rs1128503
0.040 GeneticVariation BEFREE Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer. 19415305

2009

dbSNP: rs1128503
rs1128503
0.040 GeneticVariation BEFREE In particular, carriers of the T/T genotype in exon 12 (1236 C-->T) SNP and the T/T genotype in exon 21 (2677G-->T) SNP were most significantly associated with a higher risk for developing MSI-H CRC compared to controls (P=0.01, OR=3.182 and P=0.005, OR=3.594, respectively). 18474294

2008