| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.050 | GeneticVariation | BEFREE | This meta-analysis suggests that the MTR A2756G polymorphism is not associated with CRC/CRA susceptibility and that gene-environment interaction may exist. | 23593229 | 2013 |
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0.050 | GeneticVariation | BEFREE | No significant association was found between MTHFR A1298C and MTR A2756G polymorphisms and the risk of CRC. | 22719222 | 2012 |
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0.050 | GeneticVariation | BEFREE | The A2756G MTR polymorphism was not associated with the risk of developing CRC. | 18996879 | 2008 |
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0.050 | GeneticVariation | BEFREE | We evaluated the relation between the polymorphisms 677C --> T of the methylenetetrahydrofolate reductase (MTHFR) and 2756A --> G of the methionine synthase (MTR) genes and risk of colorectal cancer. | 15598777 | 2004 |
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0.050 | GeneticVariation | BEFREE | In this study, we examined the relationship of a polymorphism (2756A-->G, asp-->gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls. | 10498402 | 1999 |
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0.020 | GeneticVariation | BEFREE | Results for other variants varied across individual studies; in our meta-analyses we observed some evidence for SHMT 1420C>T (rs1979277) ((odds ratio) OR = 0.85; 95% confidence interval (CI) = 0.73-1.00 for TT v. CC) and TYMS 5' 28 bp repeat (rs34743033) and CRC risk (OR = 0.84; 95% CI = 0.75-0.94 for 2R/3R v. 3R/3R and OR = 0.82; 95% CI = 0.69-0.98 for 2R/2R v. 3R/3R). | 23401104 | 2013 |
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0.020 | GeneticVariation | BEFREE | Similarly, homozygosity for the C1420T SHMT polymorphism also had a 2.6-fold increased risk (95% CI: 1.1, 5.9) of developing CRC. | 18996879 | 2008 |
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|
0.010 | GeneticVariation | BEFREE | These two linked (r(2) = 0.99) tagSNPs and one tagSNP in the MTR gene (rs4659744) were significantly associated with reduced colorectal cancer risk only among individuals not using multivitamin supplements. | 20615890 | 2010 |