DisGeNET - a database of gene-disease associations

Colorectal Neoplasms, C0009404

Gene: KRAS ×

Source: CLINVAR ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.

22734028

2012

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.

20978259

2010

dbSNP:

rs121913529

KRAS

0.700

CausalMutation

CLINVAR

BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.

19881948

2009

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival.

26623049

2015

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.

21398618

2011

dbSNP:

rs121913528

KRAS

0.700

GeneticVariation

CLINVAR

Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.

21398618

2011

dbSNP:

rs121913529

KRAS

0.700

CausalMutation

CLINVAR

Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.

21398618

2011

dbSNP:

rs1057519725

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913238

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913240

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913240

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913527

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913529

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913529

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913529

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913535

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913535

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs121913535

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs17851045

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011

dbSNP:

rs17851045

KRAS

0.700

CausalMutation

CLINVAR

Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.

21228335

2011