Gene: BRAF ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. 23845441

2013
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. 19794125

2009
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. 22180495

2012
dbSNP: rs121913361
rs121913361
BRAF
G 0.700 CausalMutation CLINVAR Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. 22180495

2012
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR BRAF as a target for cancer therapy. 21426297

2011
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. 20857202

2011
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis. 21716161

2011
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis. 24594804

2014
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs121913338
rs121913338
BRAF
C 0.700 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs121913355
rs121913355
BRAF
T 0.700 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs121913355
rs121913355
BRAF
G 0.700 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs121913355
rs121913355
BRAF
A 0.700 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs121913361
rs121913361
BRAF
G 0.700 CausalMutation CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845

2009
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 23549875

2013
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338

2012
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. 22535154

2012
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. 20619739

2010
dbSNP: rs121913338
rs121913338
BRAF
C 0.700 CausalMutation CLINVAR Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. 20619739

2010
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. 22448344

2012
dbSNP: rs727502902
rs727502902
BRAF
TGTA 0.700 CausalMutation CLINVAR Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. 21190184

2011
dbSNP: rs113488022
rs113488022
BRAF
T 0.790 CausalMutation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913338
rs121913338
BRAF
C 0.700 CausalMutation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 CausalMutation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016