Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10757274
rs10757274
G 0.900 GeneticVariation GWASCAT Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. 22751097

2012

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASDB A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. 22319020

2012

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE To address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts. 22436605

2012

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured. 21804106

2012

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASDB Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. 22751097

2012

dbSNP: rs671
rs671
A 0.900 GeneticVariation GWASCAT Genome-wide association study of coronary artery disease in the Japanese. 21971053

2012

dbSNP: rs671
rs671
A 0.900 GeneticVariation GWASDB Genome-wide association study of coronary artery disease in the Japanese. 21971053

2012

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282

2011

dbSNP: rs1333049
rs1333049
C 0.900 GeneticVariation GWASCAT A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. 21606135

2011

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASDB Two-marker association tests yield new disease associations for coronary artery disease and hypertension. 21626137

2011

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Independent association of the variant rs1333049 at the 9p21 locus and coronary heart disease. 21874923

2011

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASDB Large-scale gene-centric analysis identifies novel variants for coronary artery disease. 21966275

2011

dbSNP: rs1333049
rs1333049
C 0.900 GeneticVariation GWASDB A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. 21606135

2011

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). 20231156

2010

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE The results showed that 3 SNPs in whites (rs599839, rs1333049, and rs501120; HRRs were 1.10 (P = 0.044), 1.14 (P < 0.001), and 1.14 (P = 0.030), respectively) and 1 SNP in African Americans (rs7250581; HRR = 1.60, P = 0.05) were significantly associated with incident CHD. 19955471

2010

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined. 20400779

2010

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels. 20417517

2010

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE A single-nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to predict coronary heart disease (CHD) in whites. 20031596

2009

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites. 19329499

2009

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study. 19171343

2009

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE SNP rs1333049 on chromosome 9p21.3 was associated with both CHD and stroke (HR=1.20, 95% CI 1.08-1.34 for incident CHD events and 1.15, 0.99-1.34 for incident stroke). 18979498

2009

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE Although overall, rs10757274 did not add substantially to the usefulness of the FRS for predicting future events, it did improve reclassification of CHD risk, and thus may have clinical utility. 18250146

2008

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively). 18957718

2008

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE We confirmed the associations between four polymorphisms and CHD, the rs1151640 polymorphism in the olfactory receptor family 13 subfamily G member 1 (OR13G1) gene (HR 1.14, 95% CI 1.01-1.28, P = 0.03), the rs11881940 polymorphism in the heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1) gene (HR 1.27, 95% CI 1.07-1.51, P = 0.007), the rs3746731 polymorphism in the complement component 1 q subcomponent receptor 1 (CD93) gene (HR 1.26, 95% CI 1.06-1.49, P = 0.01), and the rs10757274 polymorphism near the cyclin-dependent kinase N2A and N2B (CDKN2A and CDKN2B) genes (HR 1.39, 95% CI 1.15-1.69, P < 0.001). 18599554

2008

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274. 18925945

2008