rs2228671
|
|
|
0.730 |
GeneticVariation |
BEFREE |
We concluded that the heterozygosity in LDLR-rs72658855and rs2228671 and T allele in LDLR rs2228671are strongly associated with an increased susceptibility to coronary artery disease.
|
31613733 |
2020 |
rs2228671
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Meta-analysis has established rs2228671 as a protective factor of CHD in Europeans.
|
24900971 |
2014 |
rs2228671
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs2228671
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs1122608, rs2228671, and rs688) and FVIII coagulant activity (FVIII:c) in subjects with (n = 692) or without (n = 291) angiographically confirmed coronary artery disease (CAD).
|
20810930 |
2010 |
rs6511720
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The phenotype-genotype analysis showed that the rs6511720 minor allele is associated with lower level of LDL-C [beta = -0.2209, p = 3.85 x10-262], and lower risk of CHD [log (OR) = 0.1155, p = 1.04 x10-7].Rs6511720 is in complete linkage.
|
27973560 |
2016 |
rs6511720
|
|
|
0.720 |
GeneticVariation |
BEFREE |
LDLR rs6511720 is associated with AAA.This finding is consistent with established effects of this variant on coronary artery disease.
|
24046328 |
2013 |
rs6511720
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs6511720
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
|
21966275 |
2011 |
rs72658855
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A non-significant association was reported in recessive inheritance model for variant (CC+CT) vs. TT OR 0.56(0.16-1.95), P<0.36. and in dominant inheritance model for variant CC vs. (CT+TT) OR 2.8(1.07-7.34),P<0.032 .In case of allelic comparison, it was indicated that the LDLR rs2228671-T allele was associated with an increased risk of developing risk of CAD compared to C allele OR=2.4, 95% CI (1.05-5.64) P< 0.036 .Our findings showed that LDLR rs72658855 C>T gene variability is associated with an increased susceptibility to coronary artery disease in codominant inheritance model for variant CC vs. CT OR 1.7(1.1-2.6), P<0.015 and in dominant inheritance model for variant CC vs. (CT+TT) OR 1.66(1.07-2.58),P<0.0.02.
|
31613733 |
2020 |
rs761954844
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C308Y mutation in LDL-R results in approximately 70% loss of LDL-R activity, leading to the elevation of low density lipoprotein-cholesterol (LDL-C) and an increased risk of premature coronary heart disease (CHD).
|
31706281 |
2019 |
rs688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs1122608, rs2228671, and rs688) and FVIII coagulant activity (FVIII:c) in subjects with (n = 692) or without (n = 291) angiographically confirmed coronary artery disease (CAD).
|
20810930 |
2010 |
rs879254920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, these data confirm the absence of a significant impact of the A370T polymorphism on LDL receptor function, at least as measured by the effect on plasma lipid levels and CHD risk.
|
17044844 |
2006 |
rs879254960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, these data confirm the absence of a significant impact of the A370T polymorphism on LDL receptor function, at least as measured by the effect on plasma lipid levels and CHD risk.
|
17044844 |
2006 |
rs1249040838
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K allele of the R219K variant was significantly more frequent in FH subjects without premature CHD (0.32, 95% CI 0.27 to 0.37) than in FH subjects with premature CHD (0.25, 95% CI 0.21 to 0.29) (p<0.05), suggesting that the genetic variant R219K in ABCA1 could influence the development and progression of atherosclerosis in FH subjects.
|
12624133 |
2003 |
rs544456198
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1.
|
12646194 |
2003 |
rs752596535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1.
|
12646194 |
2003 |
rs1035071612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population.
|
11357934 |
2001 |