Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD. 31770616

2020

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is an established genetic risk of hypertension, diabetes, and coronary heart diseases in Asian population. 30846829

2020

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Gender-based subgroup tests showed that four polymorphisms (rs75227345, rs2383205, rs10738606 and rs1333049) were associated with CHD in males (p < .05). 31496134

2019

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Six common variants at ALDH2 gene, including rs2339840, rs4648328, rs4767939, rs11066028, rs16941669, and rs671, were selected to test the associations of those polymorphisms with the cardiovascular outcome in patients with CHD after PCI. 29742731

2018

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management. 29960587

2018

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population. 28639227

2017

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population. 28962556

2017

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022). 27741513

2016

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08). 26950853

2016

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease. 27191745

2016

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population. 25592106

2015

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity. 25257646

2015

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE We genotyped rs671 of ALDH2 in 96 coronary heart disease (CHD) patients with four methods including high resolution melting analysis (HRM), TaqMan allelic discrimination assay (TaqMan), allele-specific PCR (AS-PCR) and pyrosequencing. 25803854

2015

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE This study confirms the association between 9p21 (rs1333049) and fatal CHD in a Norwegian population-based cohort. 24728607

2014

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation BEFREE Our case-control study and meta-analysis suggest that rs1333049 is a useful risk marker of CHD. 24930384

2014

dbSNP: rs1333049
rs1333049
C 0.900 GeneticVariation GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325

2014

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE The association between the aldehyde dehydrogenase 2 (ALDH2, rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls. 24067347

2014

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis. 24333098

2014

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease. 25263942

2014

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population. 23569135

2013

dbSNP: rs1333049
rs1333049
0.900 GeneticVariation GWASDB A genome-wide association study of a coronary artery disease risk variant. 23364394

2013

dbSNP: rs671
rs671
0.900 GeneticVariation BEFREE Our meta-analysis results showed that the A variant of the ALDH2 rs671 polymorphism may be associated with increase risks of CHD (odds ratios [OR]=1.36, 95% confidence interval [CI]=1.06-1.75, p=0.017) and MI (OR=1.64, 95% CI=1.22-2.20, p=0.001). 23697560

2013

dbSNP: rs10757274
rs10757274
0.900 GeneticVariation BEFREE The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured. 21804106

2012

dbSNP: rs10757274
rs10757274
G 0.900 GeneticVariation GWASDB Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. 22751097

2012