|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Previous studies have identified that genetic variations at rs2066844, rs2066845, rs2066847 are associated with diminished enteric α-defensins in ileal Crohn's disease (CD).
|
31403980 |
2019 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
In contrast to the strong associations of the NOD2 SNPs rs2066844 (p=3.51 x 10(-3)), rs2066845 (p=1.54 x 10(-2)), and rs2066847 (p=1.61 x 10(-20)) with CD susceptibility, no significant association of rs72796353 with CD or UC susceptibility was found.
|
26147989 |
2015 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p = 2.99×10(-5)), while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p = 0.35).
|
25365249 |
2014 |
|
rs2066847
|
|
T |
0.890 |
GeneticVariation |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs2066847
|
|
T |
0.890 |
GeneticVariation |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Three NOD2/CARD15 variants, namely two missense polymorphisms R702W (rs2066844) and G908R (rs2066845), and a frame shift polymorphism L1007fs (rs2066847), were associated with CD in Caucasian populations.
|
21734346 |
2011 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
20570966 |
2010 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).
|
21209938 |
2010 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Genotyping for the NOD2 variants in exon 4 (p.Arg702Trp [rs2066844]), exon 8 (p.Gly908Arg [rs2066845]), and exon 11 (p.1007fs [rs2066847]) was performed in 52 white children with HD (41 boys, 11 girls), 152 healthy controls, and 152 children with CD (onset of disease <17 years; mean, 11.8 years).
|
20850627 |
2010 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
20570966 |
2010 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The 3 NOD2 single-nucleotide polymorphism mutations (rs2066844, rs2066845, and rs2066847) previously identified as associated with Crohn's disease were genotyped using polymerase chain reaction.
|
20940596 |
2010 |
|
rs2066847
|
|
C |
0.890 |
GeneticVariation |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs2066847
|
|
C |
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
rs2066847
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity.
|
16416181 |
2005 |