The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC.
Except for rs4263839 polymorphism, significant associations were found between the rest six TNFSF15 polymorphisms and CD risk (rs3810936: OR = 2.10, 95% CI, 1.47-3.00; rs6478108: OR = 2.19, 95% CI, 1.53-3.13; rs4979462: OR = 1.89, 95% CI, 1.42-2.52; rs6478109: OR = 2.00, 95% CI, 1.39-2.88; rs7848647: OR = 1.54, 95% CI, 1.15-2.06; rs7869487: OR = 1.51, 95% CI, 1.06-2.17).
A total of 666 IBD families (corresponding to 2,982 relatives) with European ancestry were genotyped for the rs6478108 and rs7869487 polymorphisms, which define the main TNFSF15 haplotypes previously associated with CD.