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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
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18347599 |
2008 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
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29331787 |
2018 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
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20667416 |
2011 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
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22610920 |
2012 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
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26756166 |
2016 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
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20097294 |
2010 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
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18450378 |
2008 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
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26393465 |
2015 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
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17911362 |
2007 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity.
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18721847 |
2008 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
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27852165 |
2017 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models.
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26795846 |
2016 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
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15913870 |
2005 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
BDNF Val66Met genotype and 6-month remission rates in late-life depression.
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20195291 |
2011 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
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26462036 |
2015 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression.
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23303061 |
2013 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
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29535036 |
2019 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels.
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22883353 |
2012 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects.
|
21577214 |
2012 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers.
|
18548532 |
2009 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
|
17700574 |
2007 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
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21692988 |
2011 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
|
17482146 |
2007 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression.
|
18852698 |
2010 |